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PROSPECTUS SUPPLEMENT NO. THREE
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This filing is made pursuant to Rule 424(b)(3) |
(TO PROSPECTUS DATED FEBRUARY 13, 2006)
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under the Securities Act of 1933 |
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in connection with Registration No. 333-131517 |
Common Stock
This Prospectus Supplement No. Three supplements and amends the prospectus dated February
13, 2006 relating to the resale by Kingsbridge Capital Limited, or Kingsbridge, of up to 9,218,165
shares of our common stock.
This prospectus supplement should be read in conjunction with the prospectus dated February
13, 2006, as supplemented by Prospectus Supplement No. One dated March 20, 2006 and Prospectus
Supplement No. Two dated June 1, 2006, all of which are to be delivered with this prospectus
supplement. This prospectus supplement is not complete without, and may not be delivered or
utilized except in connection with, the prospectus, including any amendments or supplements to it.
We are filing this prospectus supplement to reflect a draw down by us pursuant to the common
stock purchase agreement we entered into with Kingsbridge on February 3, 2006. The table appearing
under the caption “Selling Stockholder” on page 26 of the prospectus is hereby supplemented by
adding the following to the end of footnote (2) to that table, immediately after the paragraph and
bullet point added by Prospectus Supplement No. Two:
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On September 15, 2006, we delivered notice to Kingsbridge to effect a
draw down of up to $9.9 million. The first trading day of the eight
day pricing period for this draw down was September 18, 2006. In
connection with this draw down, we issued an aggregate of 1,371,684
shares of our common stock to Kingsbridge at an aggregate purchase
price of $9.9 million. The settlement dates for this drawdown were
September 22, 2006 and September 28, 2006.” |
Investing in our securities involves a high degree of risk. Please carefully consider the
“Risk Factors” beginning on page 5 of the prospectus, as well as the section entitled “Risk
Factors” included in our recent quarterly and annual reports filed with the Securities and Exchange
Commission.
Neither the Securities and Exchange Commission nor any state securities commission has
approved or disapproved of these securities or determined if this prospectus is truthful or
complete. Any representation to the contrary is a criminal offense.
The date of this prospectus supplement is September 28, 2006.