| In millions, except per share items | Dec-31-21 | Dec-31-20 | Dec-31-19 | Dec-31-18 | Dec-31-17 | Dec-31-16 | Dec-31-15 | Dec-31-14 |
| | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K |
| Revenues: |
| North America | | | | 45.3 | | | | |
| United States | | | | | 2.3 | | | |
| Collaboration and License | | | | 41.7 | 2.1 | | | |
| Total revenues | 351.4 | 271.0 | 103.7 | 51.5 | 2.6 | 0.1 | 0.0 | 0.0 |
| Revenue growth [+] | 29.7% | 161.3% | 101.4% | 1871.5% | 1863.9% | | | |
| Collaboration and License | | | | 1851.9% | | | | |
| Europe | | | | 1538.7% | | | | |
| Cost of goods sold | 0.0 | 0.0 | 0.0 | 1.1 | 0.0 | 0.0 | 0.0 | 0.0 |
| Gross profit | 351.4 | 271.0 | 103.7 | 50.3 | 2.6 | 0.1 | 0.0 | 0.0 |
| Gross margin | 100.0% | 100.0% | 100.0% | 97.8% | 100.0% | 100.0% | | |
| Selling, general and administrative [+] | | | | 127.7 | 99.9 | 64.9 | 33.0 | 10.8 |
| General and administrative | 0.0 | 0.0 | 0.0 | | | | | 10.8 |
| Research and development | | | | 294.0 | 231.6 | 183.2 | 114.7 | 46.0 |
| Other operating expenses | 804.2 | 455.4 | 500.5 | -170.3 | | | | |
| EBITDA [+] | -439.5 | -172.2 | -388.3 | -181.5 | -323.1 | -244.6 | -146.4 | -56.1 |
| EBITDA growth | 155.3% | -55.7% | 113.9% | -43.8% | 32.1% | 67.1% | 160.9% | 76.2% |
| EBITDA margin | -125.1% | -63.5% | -374.4% | -352.5% | -12370.5% | -183897.0% | | |
| Depreciation and amortization | 13.2 | 12.3 | 8.5 | 19.5 | 5.8 | 3.4 | 1.4 | 0.7 |
| EBIT [+] | -452.7 | -184.4 | -396.8 | -201.1 | -328.9 | -248.0 | -147.7 | -56.8 |
| EBIT growth | 145.5% | -53.5% | 97.4% | -38.9% | 32.6% | 67.9% | 160.2% | 75.9% |
| EBIT margin | -128.8% | -68.0% | -382.6% | -390.4% | -12593.5% | -186471.4% | | |
| Non-recurring items [+] | | | | 170.3 | | | | |
| Loss (gain) on sale of assets | | | | 170.3 | | | | |
| Interest income | 1.9 | 7.0 | 13.2 | 9.5 | 4.1 | 3.8 | 2.3 | 0.6 |
| Interest income | 1.9 | 7.0 | 13.2 | 9.5 | 4.1 | 3.8 | 2.3 | 0.6 |
| Other income (expense), net [+] | -2.2 | -8.0 | -15.9 | 164.7 | 6.5 | -1.6 | -0.2 | -3.6 |
| Other | -0.2 | -0.9 | -2.6 | -5.6 | 6.5 | -1.6 | -0.2 | -3.6 |
| Pre-tax income | -453.0 | -185.4 | -399.4 | -197.1 | -318.3 | -245.8 | -145.6 | -59.8 |
| Income taxes | 1.0 | 1.2 | 3.3 | 0.5 | -16.2 | 0.0 | 0.0 | 0.0 |
| Tax rate | | | | | 5.1% | | 0.0% | 0.0% |
| Net income | -454.0 | -186.6 | -402.7 | -197.6 | -302.1 | -245.9 | -145.6 | -64.6 |
| Net margin | -129.2% | -68.8% | -388.3% | -383.7% | -11567.3% | -184867.7% | | |
| |
| Basic EPS [+] | ($6.70) | ($3.07) | ($7.12) | ($3.97) | ($7.12) | ($6.21) | ($3.96) | ($2.25) |
| Growth | 118.4% | -56.9% | 79.3% | -44.2% | 14.6% | 56.9% | 76.2% | -84.9% |
| Diluted EPS [+] | ($6.70) | ($3.07) | ($7.12) | ($3.97) | ($7.12) | ($6.21) | ($3.96) | ($2.25) |
| Growth | 118.4% | -56.9% | 79.3% | -44.2% | 14.6% | 56.9% | 76.2% | -84.0% |
| |
| |
| Shares outstanding (basic) [+] | 67.8 | 60.8 | 56.6 | 49.8 | 42.5 | 39.6 | 36.8 | 28.8 |
| Growth | 11.4% | 7.5% | 13.7% | 17.2% | 7.2% | 7.6% | 27.9% | 750.1% |
| Shares outstanding (diluted) [+] | 67.8 | 60.8 | 56.6 | 49.8 | 42.5 | 39.6 | 36.8 | 28.8 |
| Growth | 11.4% | 7.5% | 13.7% | 17.2% | 7.2% | 7.6% | 27.9% | 702.4% |
| |
| EBIT is a non-GAAP figure that excludes all non-recurring expenses: restructuring costs, asset impairments, IPR&D writeoffs, and other unusual charges. |