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In millions, except per share items | Dec-31-15 | Dec-31-14 | Dec-31-13 | Dec-31-12 | Dec-31-11 | Dec-31-10 | Dec-31-09 | Dec-31-08 |
| 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K |
Revenues: |
Clinical | 509.9 | 441.1 | 359.9 | 286.3 | 236.1 | 173.8 | 124.0 | |
Non-Clinical | 28.7 | 29.0 | 41.4 | 44.9 | 41.5 | 33.1 | 41.1 | |
Other | | | | | | 5.6 | 5.4 | |
Total revenues [+] | 538.6 | 470.1 | 401.3 | 331.2 | 277.6 | 212.5 | 170.6 | 169.6 |
Royalties | 115.8 | 96.9 | 80.2 | 71.7 | 59.4 | | | 43.3 |
Products | | | | | 277.6 | 206.9 | 165.2 | 159.4 |
Other | | | | | | 5.6 | 5.4 | 10.2 |
Revenue growth [+] | 14.6% | 17.2% | 21.2% | 19.3% | 30.6% | 24.5% | 0.6% | 31.0% |
Clinical | 15.6% | 22.6% | 25.7% | 21.3% | 35.8% | 40.1% | | |
Non-Clinical | -1.2% | -29.9% | -7.9% | 8.2% | 25.5% | -19.6% | | |
Cost of goods sold [+] | 275.7 | 234.5 | 215.4 | 160.5 | 127.7 | 111.9 | 103.7 | 100.8 |
Cost of product sales | 269.9 | 229.3 | 207.9 | 153.4 | 122.8 | 105.1 | 95.5 | 89.7 |
Other cost of sales | | | | | 4.9 | 6.8 | 8.2 | 11.1 |
Contract costs | 5.8 | 5.2 | 7.5 | 7.2 | | | | |
Gross profit | 262.9 | 235.7 | 185.8 | 170.7 | 149.9 | 100.5 | 66.9 | 68.8 |
Gross margin | 48.8% | 50.1% | 46.3% | 51.5% | 54.0% | 47.3% | 39.2% | 40.6% |
Selling, general and administrative [+] | 178.0 | 152.9 | 121.7 | 105.2 | 86.7 | 63.4 | 50.4 | 50.6 |
Sales and marketing | 115.4 | 97.8 | 79.9 | 61.9 | 50.7 | 38.8 | 29.2 | 29.8 |
General and administrative | 62.6 | 55.0 | 41.7 | 43.3 | 36.0 | 24.5 | 21.3 | 20.9 |
Research and development | 115.8 | 96.9 | 80.2 | 71.7 | 59.4 | 42.5 | 39.3 | 43.3 |
Other operating expenses | | | -1.3 | | | -0.3 | | |
EBITDA [+] | -3.6 | 7.5 | 3.1 | 7.2 | 14.1 | 4.3 | -14.1 | -11.9 |
EBITDA growth | -148.0% | 145.8% | -57.7% | -48.8% | 229.6% | -130.5% | 18.3% | -19.3% |
EBITDA margin | -0.7% | 1.6% | 0.8% | 2.2% | 5.1% | 2.0% | -8.2% | -7.0% |
Depreciation | 21.0 | 16.9 | 12.4 | 8.5 | 3.8 | 2.4 | 2.0 | 7.6 |
EBITA | -24.6 | -9.3 | -9.3 | -1.2 | 10.3 | 1.9 | -16.1 | -19.5 |
EBITA margin | -4.6% | -2.0% | -2.3% | -0.4% | 3.7% | 0.9% | -9.4% | -11.5% |
Amortization of intangibles | 6.3 | 4.7 | 5.4 | 5.0 | 6.5 | 7.0 | 6.8 | 5.6 |
EBIT [+] | -30.9 | -14.1 | -14.7 | -6.2 | 3.8 | -5.0 | -22.9 | -25.1 |
EBIT growth | 119.1% | -4.2% | 136.7% | -262.9% | -175.6% | -77.9% | -8.9% | -0.2% |
EBIT margin | -5.7% | -3.0% | -3.7% | -1.9% | 1.4% | -2.4% | -13.4% | -14.8% |
Non-recurring items [+] | | 20.0 | 1.3 | 15.1 | | 0.3 | 0.5 | -1.5 |
Asset impairment | | | 1.3 | | | 0.3 | | |
Legal settlement | | 20.0 | | 15.1 | | | -0.2 | -1.5 |
Interest expense, net [+] | 12.8 | 11.5 | 0.1 | 0.1 | 0.5 | 0.2 | -0.1 | -1.2 |
Interest expense | 14.7 | 12.6 | 0.1 | 0.1 | 0.5 | 0.3 | 0.3 | 0.0 |
Interest income | 1.9 | 1.1 | 0.0 | 0.0 | 0.0 | 0.2 | 0.4 | 1.2 |
Other income (expense), net [+] | -3.6 | -2.0 | -0.7 | 0.1 | -0.7 | -0.8 | 0.4 | -0.9 |
Gain (loss) on foreign currency transactions | -3.6 | -2.0 | -0.7 | 0.1 | -0.7 | -0.8 | 0.4 | -0.9 |
Other | -16.4 | -13.5 | -0.8 | 0.0 | -1.1 | -1.0 | 0.4 | 0.4 |
Pre-tax income | -47.3 | -47.6 | -16.8 | -21.3 | 2.7 | -6.3 | -22.9 | -23.3 |
Income taxes | 1.3 | 2.6 | 1.1 | -1.3 | 0.0 | -0.4 | -0.4 | -0.9 |
Tax rate | | | | 6.0% | 1.7% | 6.6% | 1.9% | 3.9% |
Net income | -48.5 | -50.1 | -18.0 | -20.0 | 2.6 | -5.9 | -22.5 | -22.4 |
Net margin | -9.0% | -10.7% | -4.5% | -6.1% | 0.9% | -2.8% | -13.2% | -13.2% |
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Basic EPS [+] | ($0.67) | ($0.72) | ($0.27) | ($0.30) | $0.04 | ($0.10) | ($0.39) | ($0.39) |
Growth | -5.7% | 168.9% | -12.6% | -827.3% | -142.3% | -74.4% | -1.4% | -2.0% |
Diluted EPS [+] | ($0.67) | ($0.72) | ($0.27) | ($0.30) | $0.04 | ($0.10) | ($0.39) | ($0.39) |
Growth | -5.7% | 168.9% | -12.6% | -873.8% | -139.7% | -74.4% | -1.4% | -2.0% |
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Shares outstanding (basic) [+] | 71.9 | 70.1 | 67.5 | 65.8 | 62.7 | 59.7 | 58.2 | 57.1 |
Growth | 2.7% | 3.8% | 2.5% | 4.9% | 5.1% | 2.6% | 1.9% | 3.3% |
Shares outstanding (diluted) [+] | 71.9 | 70.1 | 67.5 | 65.8 | 66.8 | 59.7 | 58.2 | 57.1 |
Growth | 2.7% | 3.8% | 2.5% | -1.4% | 11.8% | 2.6% | 1.9% | 3.3% |
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EBIT is a non-GAAP figure that excludes all non-recurring expenses: restructuring costs, asset impairments, IPR&D writeoffs, and other unusual charges. |
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