| In millions, except per share items | Dec-31-22 | Dec-31-21 | Dec-31-20 | Dec-31-19 | Dec-31-18 | Dec-31-17 | Dec-31-16 | Dec-31-15 |
| | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K |
| Revenues: |
| JAPAN | 56.5 | 16.0 | | | | | | |
| UNITED STATES | 186.0 | 159.5 | | | | | | |
| Other | 2.9 | 12.9 | | | | | | |
| Total revenues [+] | 245.4 | 188.5 | 164.4 | 136.5 | 9.8 | 0.0 | 0.0 | 0.0 |
| Products | 245.4 | 188.5 | | | | | | |
| Revenue growth [+] | 30.2% | 14.6% | 20.5% | 1287.6% | | | | |
| JAPAN | 253.0% | | | | | | | |
| UNITED STATES | 16.6% | | | | | | | |
| Cost of goods sold | 55.1 | 44.2 | 39.9 | 24.2 | 2.4 | 0.0 | 0.0 | 0.0 |
| Gross profit | 190.2 | 144.3 | 124.5 | 112.3 | 7.4 | 0.0 | 0.0 | 0.0 |
| Gross margin | 77.5% | 76.6% | 75.7% | 82.3% | 75.4% | | | |
| Selling, general and administrative [+] | 265.8 | 234.3 | 203.6 | 210.8 | 168.2 | 79.2 | 50.7 | 43.2 |
| General and administrative | 265.8 | 234.3 | 203.6 | 210.8 | 168.2 | 79.2 | 50.7 | 43.2 |
| Research and development | 397.5 | 272.7 | 181.2 | 131.7 | 145.3 | 109.7 | 122.7 | 74.3 |
| EBITDA [+] | -467.8 | -353.6 | -251.1 | -225.1 | -302.5 | -186.0 | -171.0 | -115.5 |
| EBITDA growth | 32.3% | 40.8% | 11.6% | -25.6% | 62.6% | 8.8% | 48.0% | 33.9% |
| EBITDA margin | -190.7% | -187.6% | -152.7% | -164.9% | -3075.9% | | | |
| Depreciation | 5.3 | 9.1 | 9.1 | 5.2 | 3.6 | 2.9 | 2.4 | 2.0 |
| EBITA | -473.1 | -362.7 | -260.2 | -230.3 | -306.1 | -188.9 | -173.4 | -117.5 |
| EBITA margin | -192.8% | -192.5% | -158.3% | -168.7% | -3112.2% | | | |
| Amortization of intangibles | 5.1 | 5.1 | 5.0 | 5.0 | 1.2 | | | |
| EBIT [+] | -478.1 | -367.8 | -265.2 | -235.2 | -307.3 | -188.9 | -173.4 | -117.5 |
| EBIT growth | 30.0% | 38.7% | 12.7% | -23.5% | 62.7% | 9.0% | 47.6% | 34.5% |
| EBIT margin | -194.9% | -195.1% | -161.3% | -172.4% | -3124.9% | | | |
| Non-recurring items [+] | -20.8 | 7.3 | | | | | | |
| Loss on contingent liability | -20.8 | 7.3 | | | | | | |
| Interest expense, net [+] | 15.4 | 40.3 | 27.9 | 17.8 | 15.1 | 4.3 | 2.9 | 2.6 |
| Interest expense | 26.4 | 40.5 | 29.6 | 27.7 | 25.5 | 5.9 | 3.5 | 2.9 |
| Interest income | 11.1 | 0.2 | 1.7 | 9.9 | 10.3 | 1.6 | 0.6 | 0.3 |
| Other income (expense), net [+] | -7.5 | -21.0 | 0.4 | -0.5 | -1.6 | 0.3 | 0.1 | 0.0 |
| Gain (loss) on debt retirement | | -17.7 | | | -2.2 | | | |
| Unrealized gain/loss on derivatives | -1.5 | | | | | | | |
| Other | -5.9 | -3.3 | 0.4 | -0.5 | 0.6 | 0.3 | 0.1 | 0.0 |
| Pre-tax income | -480.2 | -436.4 | -292.7 | -253.6 | -324.1 | -192.9 | -176.2 | -120.2 |
| Income taxes | 1.4 | -1.8 | 1.4 | 0.8 | 0.2 | -0.3 | 0.1 | -2.0 |
| Tax rate | | 0.4% | | | | 0.1% | | 1.6% |
| Net income | -481.5 | -434.7 | -294.1 | -254.3 | -324.3 | -192.6 | -176.3 | -118.2 |
| Net margin | -196.3% | -230.6% | -178.9% | -186.4% | -3297.2% | | | |
| |
| Basic EPS [+] | ($3.91) | ($3.88) | ($3.01) | ($3.01) | ($4.22) | ($2.89) | ($2.85) | ($2.02) |
| Growth | 0.9% | 28.7% | 0.2% | -28.7% | 45.7% | 1.6% | 41.3% | 9.7% |
| Diluted EPS [+] | ($3.91) | ($3.88) | ($3.01) | ($3.01) | ($4.22) | ($2.89) | ($2.85) | ($2.02) |
| Growth | 0.9% | 28.7% | 0.2% | -28.7% | 45.7% | 1.6% | 41.3% | 9.7% |
| |
| Shares outstanding (basic) [+] | 123.0 | 112.1 | 97.6 | 84.6 | 76.9 | 66.6 | 61.9 | 58.6 |
| Growth | 9.7% | 14.9% | 15.4% | 10.0% | 15.5% | 7.6% | 5.6% | 36.1% |
| Shares outstanding (diluted) [+] | 123.0 | 112.1 | 97.6 | 84.6 | 76.9 | 66.6 | 61.9 | 58.6 |
| Growth | 9.7% | 14.9% | 15.4% | 10.0% | 15.5% | 7.6% | 5.6% | 36.1% |
| |
| EBIT is a non-GAAP figure that excludes all non-recurring expenses: restructuring costs, asset impairments, IPR&D writeoffs, and other unusual charges. |