| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 04/13/2011 | Shaffer James P | EVP & Chief Commercial Officer | Disposition | Stock Option (right to buy) | 7.5k | $22.63 | $169.7k | | 04/12/2011 |
| 04/13/2011 | Shaffer James P | EVP & Chief Commercial Officer | Disposition | Stock Option (right to buy) | 25k | $8.78 | $219.5k | | 04/12/2011 |
| 04/13/2011 | Shaffer James P | EVP & Chief Commercial Officer | Disposition | Stock Option (right to buy) | 15k | $18.39 | $275.8k | | 04/12/2011 |
| 04/13/2011 | Shaffer James P | EVP & Chief Commercial Officer | Disposition | Stock Option (right to buy) | 20k | $18.97 | $379.4k | | 04/12/2011 |
| 04/13/2011 | Shaffer James P | EVP & Chief Commercial Officer | Disposition | Stock Option (right to buy) | 10k | $14.91 | $149.1k | | 04/12/2011 |
| 04/13/2011 | Shaffer James P | EVP & Chief Commercial Officer | Disposition | Stock Option (Right to Buy) | 75k | $16.54 | $1.2M | | 04/12/2011 |
| 04/13/2011 | Tarriff Scott | Director | Disposition | Common Stock Warrant (right to buy) | 7.5k | $15.60 | $117k | | 04/12/2011 |
| 04/13/2011 | Shaffer James P | EVP & Chief Commercial Officer | Disposition | Stock Option (right to buy) | 67.5k | $14.73 | $994.3k | | 04/12/2011 |
| 04/13/2011 | SOBEL BURTON E | Director | Disposition | Stock Option (Right to Buy) | 15k | $16.16 | $242.4k | | 04/13/2011 |
| 04/13/2011 | Ballantyne Charles Evan | EVP, CFO | Disposition | Stock Option (right to buy) | 65k | $8.78 | $570.7k | | 04/12/2011 |
| 04/13/2011 | Ballantyne Charles Evan | EVP, CFO | Disposition | Stock Option (right to buy) | 75k | $18.39 | $1.4M | | 04/12/2011 |
| 04/13/2011 | Ballantyne Charles Evan | EVP, CFO | Disposition | Stock Option (right to buy) | 75k | $16.54 | $1.2M | | 04/12/2011 |
| 04/13/2011 | SOBEL BURTON E | Director | Disposition | Stock Option (right to buy) | 15k | $15.41 | $231.2k | | 04/13/2011 |
| 04/13/2011 | SOBEL BURTON E | Director | Disposition | Stock Option (right to buy) | 15k | $16.00 | $240k | | 04/13/2011 |
| 04/13/2011 | SOBEL BURTON E | Director | Disposition | Stock Option (right to buy) | 15k | $23.03 | $345.4k | | 04/13/2011 |
| 04/13/2011 | SOBEL BURTON E | Director | Disposition | Stock Option (right to buy) | 15k | $9.87 | $148k | | 04/13/2011 |
| 04/13/2011 | Ballantyne Charles Evan | EVP, CFO | Disposition | Stock Option (right to buy) | 75k | $8.65 | $648.8k | | 04/12/2011 |
| 04/13/2011 | Ballantyne Charles Evan | EVP, CFO | Disposition | Stock Option (right to buy) | 45k | $14.99 | $674.6k | | 04/12/2011 |
| 04/13/2011 | Ballantyne Charles Evan | EVP, CFO | Disposition | Stock Option (right to buy) | 50k | $16.95 | $847.5k | | 04/12/2011 |
| 04/13/2011 | BELBEL CAESAR J | EVP, Chief Legal Officer | Disposition | Stock Option (right to buy) | 75k | $16.54 | $1.2M | | 04/13/2011 |
| 04/13/2011 | Reed Carol | EVP and Chief Medical Officer | Disposition | Stock Option (right to buy | 45k | $12.37 | $556.6k | | 04/12/2011 |
| 04/13/2011 | Reed Carol | EVP and Chief Medical Officer | Disposition | Stock Option (right to buy | 45k | $14.99 | $674.6k | | 04/12/2011 |
| 04/13/2011 | Reed Carol | EVP and Chief Medical Officer | Disposition | Stock Option (right to buy | 85k | $18.39 | $1.6M | | 04/12/2011 |
| 04/13/2011 | Reed Carol | EVP and Chief Medical Officer | Disposition | Stock Option (right to buy) | 85k | $16.54 | $1.4M | | 04/12/2011 |
| 04/13/2011 | Wallace Richard John | Director | Disposition | Stock Option (right to buy) | 15k | $23.03 | $345.4k | | 04/12/2011 |
| 04/13/2011 | Wallace Richard John | Director | Disposition | Stock Option (right to buy) | 15k | $16.00 | $240k | | 04/12/2011 |
| 04/13/2011 | Wallace Richard John | Director | Disposition | Stock Option (right to buy) | 15k | $15.41 | $231.2k | | 04/12/2011 |
| 04/13/2011 | Wallace Richard John | Director | Disposition | Stock Option (Right to Buy) | 15k | $16.16 | $242.4k | | 04/12/2011 |
| 04/13/2011 | BELBEL CAESAR J | EVP, Chief Legal Officer | Disposition | Stock Option (right to buy) | 75k | $18.39 | $1.4M | | 04/13/2011 |
| 04/13/2011 | BELBEL CAESAR J | EVP, Chief Legal Officer | Disposition | Stock Option (right to buy) | 65k | $8.78 | $570.7k | | 04/13/2011 |
| 04/13/2011 | BELBEL CAESAR J | EVP, Chief Legal Officer | Disposition | Stock Option (right to buy) | 50k | $16.95 | $847.5k | | 04/13/2011 |
| 04/13/2011 | Fromkin Andrew J. | CEO, President | Disposition | Stock Option (right to buy) | 75k | $11.93 | $894.8k | | 04/12/2011 |
| 04/13/2011 | Fromkin Andrew J. | CEO, President | Disposition | Stock Option (right to buy) | 225k | $12.37 | $2.8M | | 04/12/2011 |
| 04/13/2011 | Fromkin Andrew J. | CEO, President | Disposition | Stock Option (right to buy) | 231.8k | $12.37 | $2.9M | | 04/12/2011 |
| 04/13/2011 | Fromkin Andrew J. | CEO, President | Disposition | Stock Option (right to buy) | 8k | $10.73 | $85.4k | | 04/12/2011 |
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