| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 09/29/2017 | ORBIMED ADVISORS LLC | 10% Owner | Sale | Common Stock, par value $0.001 per share | 93.2k | $0.74 | $69k | See Footnotes | 09/28/2017 |
| 09/29/2017 | ORBIMED ADVISORS LLC | 10% Owner | Sale | Common Stock, par value $0.001 per share | 888 | $0.74 | $657.1 | See Footnotes | 09/28/2017 |
| 09/28/2017 | ORBIMED ADVISORS LLC | 10% Owner | Sale | Common Stock, par value $0.001 per share | 377k | $0.72 | $271.4k | See Footnotes | 09/28/2017 |
| 09/28/2017 | ORBIMED ADVISORS LLC | 10% Owner | Sale | Common Stock, par value $0.001 per share | 3.6k | $0.72 | $2.6k | See Footnotes | 09/28/2017 |
| 09/27/2017 | ORBIMED ADVISORS LLC | 10% Owner | Sale | Common Stock, par value $0.001 per share | 52.3k | $0.92 | $48.1k | See Footnotes | 09/26/2017 |
| 09/27/2017 | ORBIMED ADVISORS LLC | 10% Owner | Sale | Common Stock, par value $0.001 per share | 498 | $0.92 | $458.2 | See Footnotes | 09/26/2017 |
| 09/26/2017 | ORBIMED ADVISORS LLC | 10% Owner | Sale | Common Stock, par value $0.001 per share | 74.1k | $1.03 | $76.3k | See Footnotes | 09/26/2017 |
| 09/26/2017 | ORBIMED ADVISORS LLC | 10% Owner | Sale | Common Stock, par value $0.001 per share | 706 | $1.03 | $727.2 | See Footnotes | 09/26/2017 |
| 06/28/2017 | MCGIRR DAVID W J | Director | Grant | Stock Option (right to buy) | 3k | $2.55 | $7.6k | | 06/28/2017 |
| 06/28/2017 | Doyle Michael P. | Director | Grant | Stock Option (right to buy) | 3k | $2.55 | $7.6k | | 06/28/2017 |
| 06/28/2017 | VALERIANI NICHOLAS J | Director | Grant | Stock Option (right to buy) | 3k | $2.55 | $7.6k | | 06/28/2017 |
| 03/24/2017 | Mary Beth Duseau | CEO and President | Grant | Common Stock, $0.001 par value per share | 115k | $3.45 | $396.8k | | 03/24/2017 |
| 03/24/2017 | Boesgaard Lars | Vice President, CFO | Grant | Common stock, par value $0.001 per share | 54k | $3.45 | $186.3k | | 03/24/2017 |
| 11/10/2016 | VALERIANI NICHOLAS J | Director | Conversion | Common Stock, $0.001 par value per share | 7.1k | $7.00 | $50k | | 11/10/2016 |
| 11/10/2016 | VALERIANI NICHOLAS J | Director | Conversion | Series A Convertible Preferred Stock | 50 | $0.00 | $0 | | 11/10/2016 |
| 11/10/2016 | TPG Group Holdings (SBS) Advisors, Inc. | 10% Owner | Conversion | Common Stock | 571.4k | $0.00 | $0 | See Explanation of Responses | 11/10/2016 |
| 11/10/2016 | TPG Group Holdings (SBS) Advisors, Inc. | 10% Owner | Conversion | Series A Convertible Preferred Stock | 4k | $0.00 | $0 | See Explanation of Responses | 11/10/2016 |
| 11/10/2016 | Boesgaard Lars | Vice President, CFO | Conversion | Common Stock, $0.001 par value per share | 3.6k | $7.00 | $25k | | 11/10/2016 |
| 11/10/2016 | Boesgaard Lars | Vice President, CFO | Conversion | Series A Convertible Preferred Stock | 25 | $0.00 | $0 | | 11/10/2016 |
| 11/10/2016 | Mary Beth Duseau | CEO and President | Conversion | Common Stock, $0.001 par value per share | 1.4k | $7.00 | $10k | | 11/10/2016 |
| 11/10/2016 | Mary Beth Duseau | CEO and President | Conversion | Series A Convertible Preferred Stock | 10 | $0.00 | $0 | | 11/10/2016 |
| 09/21/2016 | TPG Group Holdings (SBS) Advisors, Inc. | 10% Owner | Purchase | Series A Convertible Preferred Stock | 4k | $0.00 | $0 | See Explanation of Responses | 09/21/2016 |
| 09/21/2016 | TPG Group Holdings (SBS) Advisors, Inc. | 10% Owner | Purchase | Warrants (right to buy) | 571.4k | $0.00 | $0 | See Explanation of Responses | 09/21/2016 |
| 09/21/2016 | Viswanathan Ravi | 10% Owner | Purchase | Series A Convertible Preferred Stock | 4k | $0.70 | $2.8k | See Note 1 | 09/21/2016 |
| 09/21/2016 | Viswanathan Ravi | 10% Owner | Purchase | Warrant to Purchase Common Stock (right to buy) | 5.7M | $0.70 | $4M | See Note 1 | 09/21/2016 |
| 09/21/2016 | MOTT DAVID M | 10% Owner | Purchase | Series A Convertible Preferred Stock | 4k | $0.70 | $2.8k | See Note 1 | 09/21/2016 |
| 09/21/2016 | MOTT DAVID M | 10% Owner | Purchase | Warrant to Purchase Common Stock (right to buy) | 5.7M | $0.70 | $4M | See Note 1 | 09/21/2016 |
| 09/21/2016 | Weller Harry R | 10% Owner | Purchase | Series A Convertible Preferred Stock | 4k | $0.70 | $2.8k | See Note 1 | 09/21/2016 |
| 09/21/2016 | Weller Harry R | 10% Owner | Purchase | Warrant to Purchase Common Stock (right to buy) | 5.7M | $0.70 | $4M | See Note 1 | 09/21/2016 |
| 09/21/2016 | SILVERSTEIN JONATHAN | 10% Owner | Purchase | Series A Convertible Preferred Stock | 4k | $0.00 | $0 | See Footnotes | 09/21/2016 |
| 09/21/2016 | SILVERSTEIN JONATHAN | 10% Owner | Purchase | Series A Convertible Preferred Stock | 37.74 | $0.00 | $0 | See Footnotes | 09/21/2016 |
| 09/21/2016 | SILVERSTEIN JONATHAN | 10% Owner | Purchase | Warrants | 5.7M | $0.00 | $0 | See Footnotes | 09/21/2016 |
| 09/21/2016 | SILVERSTEIN JONATHAN | 10% Owner | Purchase | Warrants | 53.9k | $0.00 | $0 | See Footnotes | 09/21/2016 |
| 09/21/2016 | THOMAS PAUL | President and CEO | Purchase | Warrant (right to buy) | 71.4k | $0.70 | $50k | | 09/21/2016 |
| 09/21/2016 | THOMAS PAUL | President and CEO | Purchase | Series A Convertible Preferred Stock | 50 | $0.70 | $35 | | 09/21/2016 |
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