| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 04/17/2023 | TAKEDA PHARMACEUTICAL CO LTD | | Other (disposition) | Series A Convertible Preferred Stock | 1000k | $0.00 | $0 | See Explanation of Responses | 04/17/2023 |
| 01/23/2023 | Wong Stephanie | See Remarks | Payment of Exercise | Common Stock | 317 | $0.45 | $141.4 | | 01/23/2023 |
| 01/23/2023 | Molineaux Susan | PRESIDENT & CEO | Payment of Exercise | Common Stock | 526 | $0.45 | $234.6 | By Trust | 01/23/2023 |
| 01/23/2023 | Sjogren Eric | SR. VP, DRUG DISCOVERY | Payment of Exercise | Common Stock | 279 | $0.45 | $124.5 | | 01/23/2023 |
| 01/23/2023 | Molineaux Christopher | SR. VP, DEVELOPMENT | Payment of Exercise | Common Stock | 217 | $0.45 | $96.8 | By Trust | 01/23/2023 |
| 01/23/2023 | Kuriakose Emil | CHIEF MEDICAL OFFICER | Payment of Exercise | Common Stock | 79 | $0.45 | $35.2 | | 01/23/2023 |
| 07/01/2022 | TAKEDA PHARMACEUTICAL CO LTD | | Other (disposition) | Series A Convertible Preferred Stock | 1000k | $0.00 | $0 | See Explanation of Responses | 07/01/2022 |
| 07/01/2022 | TAKEDA PHARMACEUTICAL CO LTD | | Other (acquisition) | Series A Convertible Preferred Stock | 1000k | $0.00 | $0 | See Explanation of Responses | 07/01/2022 |
| 06/01/2022 | Wolff Henry Ward | Director | Grant | Stock Option (Right to Buy) | 20k | $0.20 | $4k | | 06/01/2022 |
| 06/01/2022 | PAKIANATHAN DEEPIKA | Director | Grant | Stock Option (Right to Buy) | 20k | $0.20 | $4k | | 06/01/2022 |
| 06/01/2022 | Garland J. Scott | Director | Grant | Stock Option (Right to Buy) | 20k | $0.20 | $4k | | 06/01/2022 |
| 06/01/2022 | Wise Blake | Director | Grant | Stock Option (Right to Buy) | 20k | $0.20 | $4k | | 06/01/2022 |
| 06/01/2022 | Orford Keith | Director | Grant | Employee Stock Option (Right to Buy) | 20k | $0.20 | $4k | | 06/01/2022 |
| 06/01/2022 | AGARWAL SUNIL | Director | Grant | Stock Option (Right to Buy) | 20k | $0.20 | $4k | | 06/01/2022 |
| 06/01/2022 | JONES SUZY | Director | Grant | Stock Option (Right to Buy) | 20k | $0.20 | $4k | | 06/01/2022 |
| 01/25/2022 | Parlati Francesco | SR. VP, RESEARCH | Grant | Employee Stock Option (Right to Buy) | 165k | $0.44 | $72.6k | | 01/25/2022 |
| 01/25/2022 | Kuriakose Emil | CHIEF MEDICAL OFFICER | Grant | Employee Stock Option (Right to Buy) | 215k | $0.44 | $94.6k | | 01/25/2022 |
| 01/25/2022 | Sjogren Eric | SR. VP, DRUG DISCOVERY | Grant | Employee Stock Option (Right to Buy) | 165k | $0.44 | $72.6k | | 01/25/2022 |
| 01/25/2022 | Orford Keith | Director | Grant | Employee Stock Option (Right to Buy) | 40k | $0.44 | $17.6k | | 01/25/2022 |
| 01/25/2022 | Molineaux Christopher | SR. VP, DEVELOPMENT | Grant | Employee Stock Option (Right to Buy) | 165k | $0.44 | $72.6k | | 01/25/2022 |
| 01/25/2022 | Ray Sumita | See Remarks | Grant | Employee Stock Option (Right to Buy) | 165k | $0.44 | $72.6k | | 01/25/2022 |
| 01/25/2022 | Wong Stephanie | See Remarks | Grant | Employee Stock Option (Right to Buy) | 215k | $0.44 | $94.6k | | 01/25/2022 |
| 01/25/2022 | Molineaux Susan | PRESIDENT & CEO | Grant | Employee Stock Option (Right to Buy) | 597.5k | $0.44 | $262.9k | | 01/25/2022 |
| 01/21/2022 | Wong Stephanie | See Remarks | Payment of Exercise | Common Stock | 5.6k | $0.49 | $2.7k | | 01/21/2022 |
| 01/21/2022 | Sjogren Eric | SR. VP, DRUG DISCOVERY | Payment of Exercise | Common Stock | 4.8k | $0.49 | $2.4k | | 01/21/2022 |
| 01/21/2022 | Kuriakose Emil | CHIEF MEDICAL OFFICER | Payment of Exercise | Common Stock | 666 | $0.49 | $327.3 | | 01/21/2022 |
| 01/21/2022 | Parlati Francesco | SR. VP, RESEARCH | Payment of Exercise | Common Stock | 4.8k | $0.49 | $2.4k | | 01/21/2022 |
| 01/04/2022 | Parlati Francesco | SR. VP, RESEARCH | Payment of Exercise | Common Stock | 18.1k | $0.66 | $11.9k | | 01/04/2022 |
| 01/04/2022 | Kuriakose Emil | CHIEF MEDICAL OFFICER | Payment of Exercise | Common Stock | 3.9k | $0.66 | $2.5k | | 01/04/2022 |
| 01/04/2022 | Sjogren Eric | SR. VP, DRUG DISCOVERY | Payment of Exercise | Common Stock | 18.1k | $0.66 | $11.9k | | 01/04/2022 |
| 01/04/2022 | Wong Stephanie | See Remarks | Payment of Exercise | Common Stock | 18.1k | $0.66 | $11.9k | | 01/04/2022 |
| 11/11/2021 | Orford Keith | Director | Sale | Common Stock | 48.2k | $0.88 | $42.4k | | 11/10/2021 |
| 11/10/2021 | Orford Keith | Director | Sale | Common Stock | 30k | $0.86 | $25.7k | | 11/10/2021 |
| 11/10/2021 | DRACHMAN JONATHAN G | Director | Purchase | Common Stock | 200k | $0.86 | $171.9k | | 11/10/2021 |
| 11/10/2021 | Molineaux Christopher | SR. VP, DEVELOPMENT | Purchase | Common Stock | 100k | $0.85 | $84.7k | By Trust | 11/10/2021 |
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