| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 04/04/2023 | McClellan William D. Jr. | Director | Disposition | Common Stock | 39.2k | $0.00 | $0 | | 04/04/2023 |
| 04/04/2023 | McClellan William D. Jr. | Director | Disposition | Common Stock | 2k | $0.00 | $0 | by Trust | 04/04/2023 |
| 04/04/2023 | McClellan William D. Jr. | Director | Disposition | Stock Option (Right to Buy) | 1.4k | $3.36 | $4.8k | | 04/04/2023 |
| 04/04/2023 | McClellan William D. Jr. | Director | Disposition | Non-Qualified Stock Option (right to buy) | 4.8k | $6.50 | $31.5k | | 04/04/2023 |
| 04/04/2023 | McClellan William D. Jr. | Director | Disposition | Stock Option (Right to Buy) | 9.8k | $6.58 | $64.8k | | 04/04/2023 |
| 04/04/2023 | McClellan William D. Jr. | Director | Disposition | Non-Qualified Stock Option (right to buy) | 16.5k | $3.27 | $54.1k | | 04/04/2023 |
| 04/04/2023 | McClellan William D. Jr. | Director | Disposition | Stock Option (Right to Buy) | 28.4k | $2.08 | $59.2k | | 04/04/2023 |
| 04/04/2023 | McClellan William D. Jr. | Director | Disposition | Non-Qualified Stock Option (right to buy) | 5.3k | $8.86 | $46.7k | | 04/04/2023 |
| 04/04/2023 | McClellan William D. Jr. | Director | Disposition | Stock Option (Right to Buy) | 19.3k | $3.95 | $76.4k | | 04/04/2023 |
| 04/04/2023 | Molesphini John J | EVP, Operations | Disposition | Common Stock | 92.6k | $0.00 | $0 | | 04/04/2023 |
| 04/04/2023 | Molesphini John J | EVP, Operations | Disposition | Stock Option (Right to Buy) | 49.5k | $7.75 | $383.6k | | 04/04/2023 |
| 04/04/2023 | Molesphini John J | EVP, Operations | Disposition | Stock Option (Right to Buy) | 31k | $3.49 | $108.1k | | 04/04/2023 |
| 04/04/2023 | Molesphini John J | EVP, Operations | Disposition | Stock Option (Right to Buy) | 61.9k | $2.08 | $128.9k | | 04/04/2023 |
| 04/04/2023 | Molesphini John J | EVP, Operations | Disposition | Stock Option (Right to Buy) | 16.6k | $5.95 | $98.9k | | 04/04/2023 |
| 04/04/2023 | Molesphini John J | EVP, Operations | Disposition | Stock Option (Right to Buy) | 26.5k | $5.63 | $149.4k | | 04/04/2023 |
| 04/04/2023 | Gostout Christopher J. | Chief Medical Officer | Disposition | Common Stock | 90.3k | $0.00 | $0 | | 04/04/2023 |
| 04/04/2023 | Gostout Christopher J. | Chief Medical Officer | Disposition | Stock Option (Right to Buy) | 3.4k | $2.09 | $7.2k | | 04/04/2023 |
| 04/04/2023 | Gostout Christopher J. | Chief Medical Officer | Disposition | Stock Option (Right to Buy) | 135k | $0.00 | $0 | | 04/04/2023 |
| 04/04/2023 | Gostout Christopher J. | Chief Medical Officer | Disposition | Non-Qualified Stock Option (right to buy) | 14k | $6.58 | $92.4k | | 04/04/2023 |
| 04/04/2023 | Gostout Christopher J. | Chief Medical Officer | Disposition | Stock Option (Right to Buy) | 25.4k | $3.49 | $88.8k | | 04/04/2023 |
| 04/04/2023 | Gostout Christopher J. | Chief Medical Officer | Disposition | Stock Option (Right to Buy) | 51.6k | $2.08 | $107.3k | | 04/04/2023 |
| 04/04/2023 | Gostout Christopher J. | Chief Medical Officer | Disposition | Stock Option (Right to Buy) | 11.9k | $5.95 | $70.7k | | 04/04/2023 |
| 04/04/2023 | Gostout Christopher J. | Chief Medical Officer | Disposition | Stock Option (Right to Buy) | 6.6k | $5.63 | $37.4k | | 04/04/2023 |
| 04/04/2023 | Gutteridge Mike | VP, Int'l Sales and Marketing | Disposition | Common Stock | 86.6k | $0.00 | $0 | | 04/04/2023 |
| 04/04/2023 | Gutteridge Mike | VP, Int'l Sales and Marketing | Disposition | Stock Option (Right to Buy) | 14k | $6.50 | $91k | | 04/04/2023 |
| 04/04/2023 | Gutteridge Mike | VP, Int'l Sales and Marketing | Disposition | Stock Option (Right to Buy) | 25.5k | $4.37 | $111.4k | | 04/04/2023 |
| 04/04/2023 | Gutteridge Mike | VP, Int'l Sales and Marketing | Disposition | Stock Option (Right to Buy) | 22.7k | $3.49 | $79.1k | | 04/04/2023 |
| 04/04/2023 | Gutteridge Mike | VP, Int'l Sales and Marketing | Disposition | Stock Option (Right to Buy) | 22.2k | $2.08 | $46.1k | | 04/04/2023 |
| 04/04/2023 | Gutteridge Mike | VP, Int'l Sales and Marketing | Disposition | Stock Option (Right to Buy) | 14.8k | $5.95 | $88.3k | | 04/04/2023 |
| 04/04/2023 | Gutteridge Mike | VP, Int'l Sales and Marketing | Disposition | Stock Option (Right to Buy) | 11.6k | $5.63 | $65.4k | | 04/04/2023 |
| 04/04/2023 | Black Jeffrey G. | CFO | Disposition | Common Stock | 335.3k | $0.00 | $0 | | 04/04/2023 |
| 04/04/2023 | Black Jeffrey G. | CFO | Disposition | Stock Option (Right to Buy) | 150k | $8.69 | $1.3M | | 04/04/2023 |
| 04/04/2023 | Black Jeffrey G. | CFO | Disposition | Stock Option (Right to Buy) | 120.8k | $3.95 | $477.3k | | 04/04/2023 |
| 04/04/2023 | Shimer Julie Ann | Director | Disposition | Common Stock | 36k | $0.00 | $0 | | 04/04/2023 |
| 04/04/2023 | Shimer Julie Ann | Director | Disposition | Non-Qualified Stock Option (right to buy) | 8k | $7.75 | $62k | | 04/04/2023 |
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