| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 01/19/2023 | Rice William G. | Chair, President & CEO | Grant | Common Shares | 150k | $0.00 | $0 | | 01/19/2023 |
| 01/19/2023 | Payne Fletcher | SR VP & Chief Fin. Officer | Grant | Common Shares | 100k | $0.00 | $0 | | 01/19/2023 |
| 01/19/2023 | Rice William G. | Chair, President & CEO | Grant | Employee Stock Option (Right to Buy) | 400k | $0.66 | $264k | | 01/19/2023 |
| 01/19/2023 | Ashe Carol Gail | Director | Grant | Director Stock Option (Right to Buy) | 100k | $0.66 | $66k | | 01/19/2023 |
| 01/19/2023 | Payne Fletcher | SR VP & Chief Fin. Officer | Grant | Employee Stock Option (Right to Buy) | 200k | $0.66 | $132k | | 01/19/2023 |
| 01/19/2023 | LEDRU PHILIPPE | Chief Commercial Officer | Grant | Common Shares | 100k | $0.00 | $0 | | 01/19/2023 |
| 01/19/2023 | LEDRU PHILIPPE | Chief Commercial Officer | Grant | Employee Stock Option (Right to Buy) | 200k | $0.66 | $132k | | 01/19/2023 |
| 01/19/2023 | Vincent Mark D. | Director | Grant | Director Stock Option (Right to Buy) | 100k | $0.66 | $66k | | 01/19/2023 |
| 01/19/2023 | PLATZER ERICH | Director | Grant | Director Stock Option (Right to Buy) | 100k | $0.66 | $66k | | 01/19/2023 |
| 01/19/2023 | BURGER DENIS R | Director | Grant | Director Stock Option (Right to Buy) | 100k | $0.66 | $66k | | 01/19/2023 |
| 01/19/2023 | Whitehead Warren | Director | Grant | Director Option Grant | 100k | $0.66 | $66k | | 01/19/2023 |
| 01/19/2023 | Bejar Rafael | Sr. VP, Chief Medical Officer | Grant | Common Shares | 100k | $0.00 | $0 | | 01/19/2023 |
| 01/19/2023 | Bejar Rafael | Sr. VP, Chief Medical Officer | Grant | Employee Stock Option | 200k | $0.66 | $132k | | 01/19/2023 |
| 01/19/2023 | Seizinger Bernd R. | Director | Grant | Stock Option (right to buy) | 100k | $0.66 | $66k | | 01/19/2023 |
| 09/19/2022 | Rice William G. | Chair, President & CEO | Purchase | Common Shares | 10k | $0.68 | $6.8k | | 09/19/2022 |
| 09/19/2022 | Payne Fletcher | SR VP & Chief Fin. Officer | Purchase | Common Shares | 10k | $0.68 | $6.8k | Fletcher Payne 2019 Trust | 09/19/2022 |
| 09/14/2022 | Seizinger Bernd R. | Director | Grant | Stock Option (right to buy) | 50k | $0.74 | $37k | | 09/14/2022 |
| 07/06/2022 | Rice William G. | Chair, President & CEO | Grant | Performance Stock Options | 600k | $0.81 | $486k | | 07/06/2022 |
| 06/27/2022 | Payne Fletcher | SR VP & Chief Fin. Officer | Grant | Common Stock | 1000k | $0.85 | $847.9k | | 06/27/2022 |
| 06/06/2022 | Rice William G. | Chair, President & CEO | Purchase | Common Shares | 10k | $0.97 | $9.7k | | 06/06/2022 |
| 04/13/2022 | LEDRU PHILIPPE | Chief Commercial Officer | Grant | Employee Stock Option | 600k | $1.25 | $750k | | 04/13/2022 |
| 01/18/2022 | Vincent Mark D. | Director | Grant | Director Stock Option (Right to Buy) | 50k | $0.00 | $0 | | 01/18/2022 |
| 01/18/2022 | BURGER DENIS R | Director | Grant | Director Stock Option (Right to Buy) | 50k | $1.34 | $67k | | 01/18/2022 |
| 01/18/2022 | Loewy Caroline M | | Grant | Director Stock Option (Right to Buy) | 50k | $1.34 | $67k | | 01/18/2022 |
| 01/18/2022 | Whitehead Warren | Director | Grant | Director Option Grant | 50k | $0.00 | $0 | | 01/18/2022 |
| 01/18/2022 | PLATZER ERICH | Director | Grant | Director Stock Option (Right to Buy) | 50k | $1.34 | $67k | | 01/18/2022 |
| 01/18/2022 | Rice William G. | Chair, President & CEO | Grant | Employee Option Grant | 700k | $1.34 | $938k | | 01/18/2022 |
| 01/18/2022 | Marango Jotin | Senior VP, CFO, and CBO | Grant | Employee Stock Option | 600k | $1.34 | $804k | | 01/18/2022 |
| 01/18/2022 | Bejar Rafael | Sr. VP, Chief Medical Officer | Grant | Employee Stock Option | 600k | $1.34 | $804k | | 01/18/2022 |
| 01/18/2022 | Ashe Carol Gail | Director | Grant | Director Stock Option (Right to Buy) | 50k | $1.34 | $67k | | 01/18/2022 |
| 12/20/2021 | BURGER DENIS R | Director | Purchase | Common Shares | 10k | $1.45 | $14.5k | | 12/20/2021 |
| 12/16/2021 | PLATZER ERICH | Director | Purchase | Common Shares | 50k | $1.37 | $68.5k | | 12/16/2021 |
| 12/16/2021 | PLATZER ERICH | Director | Purchase | Common Shares | 30k | $1.38 | $41.4k | | 12/16/2021 |
| 12/16/2021 | PLATZER ERICH | Director | Purchase | Common Shares | 20k | $1.40 | $28k | | 12/16/2021 |
| 12/16/2021 | Rice William G. | Chair, President & CEO | Purchase | Common Shares | 13.2k | $1.52 | $20k | | 12/16/2021 |
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