| Date | Name | Symbol | Type | Security | Shares | Price | Value | Ownership | Reported |
| 03/01/2023 | Karyopharm Therapeutics Inc. | KPTI | Sale | Common Stock | 11.2k | $3.03 | $33.9k | | 02/28/2023 |
| 02/28/2023 | Karyopharm Therapeutics Inc. | KPTI | Grant | Common Stock | 95k | $0.00 | $0 | | 02/28/2023 |
| 02/27/2023 | Karyopharm Therapeutics Inc. | KPTI | Sale | Common Stock | 2.8k | $3.04 | $8.5k | | 02/27/2023 |
| 08/31/2022 | Karyopharm Therapeutics Inc. | KPTI | Grant | Common Stock | 30k | $0.00 | $0 | | 08/31/2022 |
| 08/31/2022 | Karyopharm Therapeutics Inc. | KPTI | Grant | Stock Option (right to buy) | 45k | $5.06 | $227.7k | | 08/31/2022 |
| 06/03/2022 | Karyopharm Therapeutics Inc. | KPTI | Sale | Common Stock | 598 | $6.04 | $3.6k | | 06/03/2022 |
| 06/03/2022 | Karyopharm Therapeutics Inc. | KPTI | Sale | Common Stock | 3 | $6.07 | $18.2 | | 06/03/2022 |
| 02/28/2022 | Karyopharm Therapeutics Inc. | KPTI | Grant | Common Stock | 88.2k | $0.00 | $0 | | 02/28/2022 |
| 02/28/2022 | Karyopharm Therapeutics Inc. | KPTI | Sale | Common Stock | 2.4k | $10.24 | $24.5k | | 02/28/2022 |
| 02/28/2022 | Karyopharm Therapeutics Inc. | KPTI | Grant | Stock Option (right to buy) | 111.6k | $10.33 | $1.2M | | 02/28/2022 |
| 02/07/2022 | Karyopharm Therapeutics Inc. | KPTI | Sale | Common Stock | 3.9k | $9.86 | $38.9k | | 02/07/2022 |
| 06/01/2021 | Karyopharm Therapeutics Inc. | KPTI | Grant | Common Stock | 5.5k | $0.00 | $0 | | 06/01/2021 |
| 06/01/2021 | Karyopharm Therapeutics Inc. | KPTI | Grant | Stock Option (right to buy) | 15k | $9.15 | $137.2k | | 06/01/2021 |
| 02/25/2021 | Karyopharm Therapeutics Inc. | KPTI | Grant | Common Stock | 22k | $0.00 | $0 | | 02/25/2021 |
| 02/25/2021 | Karyopharm Therapeutics Inc. | KPTI | Grant | Stock Option (right to buy) | 60k | $14.56 | $873.1k | | 02/25/2021 |
| 02/11/2021 | Karyopharm Therapeutics Inc. | KPTI | Sale | Common Stock | 2.9k | $15.52 | $44.4k | | 02/11/2021 |
| 02/05/2021 | Karyopharm Therapeutics Inc. | KPTI | Exercise | Restricted Stock Units | 8.2k | $0.00 | $0 | | 02/05/2021 |
| 02/05/2020 | Karyopharm Therapeutics Inc. | KPTI | Grant | Stock Option (right to buy) | 87.6k | $18.00 | $1.6M | | 02/05/2020 |
| 02/05/2020 | Karyopharm Therapeutics Inc. | KPTI | Grant | Restricted Stock Units | 32.6k | $0.00 | $0 | | 02/05/2020 |
| 02/25/2019 | Karyopharm Therapeutics Inc. | KPTI | Grant | Nonstatutory Stock Option (right to buy) | 150k | $5.06 | $759k | | 02/25/2019 |
| 09/27/2018 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Grant | Performance Stock Option 2015 (right to buy) | 1.8k | $88.95 | $160.1k | | 09/27/2018 |
| 09/27/2018 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Grant | Performance Stock Option 2016 (right to buy) | 1.4k | $42.22 | $58.6k | | 09/27/2018 |
| 08/21/2018 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Grant | Performance Stock Option 2015 (right to buy) | 1.8k | $88.95 | $160.1k | | 08/21/2018 |
| 08/13/2018 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Grant | Common Stock | 1k | $0.00 | $0 | | 08/10/2018 |
| 08/13/2018 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Payment of Exercise | Common Stock | 449 | $90.95 | $40.8k | | 08/10/2018 |
| 08/10/2018 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Grant | Performance Stock Option 2013 (right to buy) | 1.7k | $63.00 | $105k | | 08/10/2018 |
| 08/10/2018 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Grant | Performance Stock Option 2014 (right to buy) | 2.8k | $96.45 | $265.2k | | 08/10/2018 |
| 07/10/2018 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Other (acquisition) | Common Stock | 23 | $0.00 | $0 | by Managed Account | 08/10/2018 |
| 04/16/2018 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Other (acquisition) | Common Stock | 22 | $0.00 | $0 | by Managed Account | 08/10/2018 |
| 03/01/2018 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Grant | Stock Option (right to buy) | 4k | $119.13 | $476.5k | | 03/01/2018 |
| 01/17/2018 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Other (acquisition) | Common Stock | 5 | $0.00 | $0 | by Managed Account | 08/10/2018 |
| 01/04/2018 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Exercise | Stock Option (right to buy) | 10k | $97.72 | $977.2k | | 01/04/2018 |
| 01/04/2018 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Exercise | Stock Option (right to buy) | 6.2k | $96.45 | $596.7k | | 01/04/2018 |
| 01/04/2018 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Exercise | Stock Option (right to buy) | 3.6k | $88.95 | $320.2k | | 01/04/2018 |
| 01/04/2018 | ALNYLAM PHARMACEUTICALS, INC. | ALNY | Exercise | Stock Option (right to buy) | 3.4k | $63.00 | $216.7k | | 01/04/2018 |
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