| Date | Name | Symbol | Type | Security | Shares | Price | Value | Ownership | Reported |
| 06/14/2022 | Zynerba Pharmaceuticals, Inc. | ZYNE | Grant | Stock Option (right to buy) | 34.7k | $1.01 | $35k | | 06/14/2022 |
| 06/14/2022 | Zynerba Pharmaceuticals, Inc. | ZYNE | Sale | Common Stock | 40 | $1.01 | $40.4 | | 06/14/2022 |
| 06/14/2022 | Zynerba Pharmaceuticals, Inc. | ZYNE | Grant | Common Stock | 23.1k | $0.00 | $0 | | 06/14/2022 |
| 08/03/2021 | Zynerba Pharmaceuticals, Inc. | ZYNE | Grant | Stock Option (right to buy) | 7.5k | $4.44 | $33.3k | | 08/03/2021 |
| 08/03/2021 | Zynerba Pharmaceuticals, Inc. | ZYNE | Grant | Common Stock | 5k | $0.00 | $0 | | 08/03/2021 |
| 06/10/2020 | Zynerba Pharmaceuticals, Inc. | ZYNE | Grant | Stock Option (right to buy) | 15k | $5.21 | $78.2k | | 06/10/2020 |
| 06/11/2019 | Zynerba Pharmaceuticals, Inc. | ZYNE | Grant | Stock Option (right to buy) | 15k | $13.50 | $202.5k | | 06/11/2019 |
| 06/06/2018 | Zynerba Pharmaceuticals, Inc. | ZYNE | Grant | Stock Option (right to buy) | 15k | $11.30 | $169.5k | | 06/06/2018 |
| 06/07/2017 | Zynerba Pharmaceuticals, Inc. | ZYNE | Grant | Stock Option (right to buy) | 15k | $18.77 | $281.6k | | 06/07/2017 |
| 05/25/2016 | Zynerba Pharmaceuticals, Inc. | ZYNE | Grant | Stock Option (right to buy) | 15k | $7.90 | $118.5k | | 05/25/2016 |
| 08/04/2015 | Zynerba Pharmaceuticals, Inc. | ZYNE | Grant | Stock Option | 35k | $14.00 | $490k | | 08/04/2015 |