| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 03/20/2019 | DUGGAN ROBERT W | 10% Owner | Sale | Common Stock, par value $0.001 per share | 50k | $0.53 | $26.5k | | 03/18/2019 |
| 03/19/2019 | DUGGAN ROBERT W | 10% Owner | Sale | Common Stock, par value $0.001 per share | 956k | $0.53 | $506.7k | | 03/18/2019 |
| 03/18/2019 | DUGGAN ROBERT W | 10% Owner | Sale | Common Stock, par value $0.001 per share | 271.9k | $0.56 | $152.3k | | 03/18/2019 |
| 03/13/2019 | DUGGAN ROBERT W | 10% Owner | Sale | Common Stock, par value $0.001 per share | 1.2M | $0.59 | $708k | | 03/11/2019 |
| 03/12/2019 | DUGGAN ROBERT W | 10% Owner | Sale | Common Stock, par value $0.001 per share | 634k | $0.61 | $386.7k | | 03/11/2019 |
| 03/11/2019 | DUGGAN ROBERT W | 10% Owner | Sale | Common Stock, par value $0.001 per share | 520.1k | $0.63 | $327.7k | | 03/11/2019 |
| 02/21/2019 | LOEB GARY | See Remarks | Sale | Common Stock | 791 | $0.89 | $704 | | 02/21/2019 |
| 02/21/2019 | Wise Blake | CEO | Sale | Common Stock | 3.8k | $0.89 | $3.4k | | 02/21/2019 |
| 02/21/2019 | Sarpangal Zeryn | CFO | Sale | Common Stock | 1.4k | $0.89 | $1.2k | | 02/21/2019 |
| 02/21/2019 | Dorling Janet | Chief Commercial Officer | Sale | Common Stock | 1.1k | $0.89 | $946.1 | | 02/21/2019 |
| 02/21/2019 | Bhatt Elizabeth | COO | Sale | Common Stock | 971 | $0.89 | $864.2 | | 02/21/2019 |
| 02/05/2019 | Dorling Janet | Chief Commercial Officer | Sale | Common Stock | 818 | $1.35 | $1.1k | | 02/05/2019 |
| 01/18/2019 | Dorling Janet | Chief Commercial Officer | Grant | Common Stock | 187.8k | $0.00 | $0 | | 01/18/2019 |
| 01/18/2019 | Bhatt Elizabeth | COO | Grant | Common Stock | 156.5k | $0.00 | $0 | | 01/18/2019 |
| 01/18/2019 | Wise Blake | CEO | Grant | Common Stock | 281.7k | $0.00 | $0 | | 01/18/2019 |
| 01/18/2019 | Sarpangal Zeryn | CFO | Grant | Common Stock | 156.5k | $0.00 | $0 | | 01/18/2019 |
| 01/18/2019 | LOEB GARY | See Remarks | Grant | Common Stock | 156.5k | $0.00 | $0 | | 01/18/2019 |
| 12/11/2018 | DUGGAN ROBERT W | 10% Owner | Purchase | Common Stock, par value $0.001 per share | 306.8k | $1.65 | $505k | | 12/10/2018 |
| 12/10/2018 | DUGGAN ROBERT W | 10% Owner | Purchase | Common Stock, par value $0.001 per share | 436.5k | $1.60 | $697.8k | | 12/10/2018 |
| 12/07/2018 | DUGGAN ROBERT W | 10% Owner | Purchase | Common Stock, par value $0.001 per share | 22.4k | $1.40 | $31.4k | | 12/07/2018 |
| 11/27/2018 | DUGGAN ROBERT W | 10% Owner | Purchase | Common Stock, par value $0.001 per share | 77.6k | $1.68 | $130k | | 11/23/2018 |
| 11/23/2018 | DUGGAN ROBERT W | 10% Owner | Purchase | Common Stock, par value $0.001 per share | 80.2k | $1.89 | $151.6k | | 11/23/2018 |
| 11/20/2018 | DUGGAN ROBERT W | 10% Owner | Purchase | Common Stock, par value $0.001 per share | 231.5k | $1.93 | $446.9k | | 11/20/2018 |
| 11/19/2018 | DUGGAN ROBERT W | 10% Owner | Purchase | Common Stock, par value $0.001 per share | 4.6k | $1.62 | $7.5k | | 11/19/2018 |
| 09/25/2018 | LOEB GARY | See Remarks | Sale | Common Stock | 1k | $4.15 | $4.3k | | 09/25/2018 |
| 09/25/2018 | Wise Blake | CEO | Sale | Common Stock | 3.2k | $4.15 | $13.5k | | 09/25/2018 |
| 09/11/2018 | Wise Blake | CEO | Grant | Stock Option (Right to Buy) | 145k | $4.79 | $694.6k | | 09/11/2018 |
| 09/11/2018 | LOEB GARY | See Remarks | Grant | Stock Option (Right to Buy) | 65k | $4.79 | $311.4k | | 09/11/2018 |
| 09/11/2018 | Bhatt Elizabeth | COO | Grant | Stock Option (Right to Buy) | 65k | $4.79 | $311.4k | | 09/11/2018 |
| 09/11/2018 | Dorling Janet | Chief Commercial Officer | Grant | Stock Option (Right to Buy) | 80k | $4.79 | $383.2k | | 09/11/2018 |
| 06/28/2018 | Hillan Kenneth J. | See Remarks | Exercise | Stock Option (Right to Buy) | 132.7k | $6.93 | $919.8k | | 06/28/2018 |
| 06/28/2018 | Hillan Kenneth J. | See Remarks | Exercise | Stock Option (Right to Buy) | 45.2k | $3.65 | $165k | | 06/28/2018 |
| 06/26/2018 | LOEB GARY | See Remarks | Grant | Common Stock | 960 | $0.00 | $0 | | 06/26/2018 |
| 06/26/2018 | LOEB GARY | See Remarks | Sale | Common Stock | 324 | $9.59 | $3.1k | | 06/26/2018 |
| 06/26/2018 | LOEB GARY | See Remarks | Grant | Stock Option (Right to Buy) | 4.5k | $10.64 | $47.9k | | 06/26/2018 |
|