| Date | Name | Symbol | Type | Security | Shares | Price | Value | Ownership | Reported |
| 10/05/2023 | Spero Therapeutics, Inc. | SPRO | Grant | Common Stock | 20k | $0.00 | $0 | | 10/05/2023 |
| 08/11/2023 | AGIOS PHARMACEUTICALS, INC. | AGIO | Exercise | Restricted stock units | 2.3k | $0.00 | $0 | | 08/11/2023 |
| 06/07/2023 | Protara Therapeutics, Inc. | PRTO | Grant | Stock Option (Right to Buy) | 10k | $2.85 | $28.5k | | 06/07/2023 |
| 06/06/2023 | Akebia Therapeutics, Inc. | AKBA | Grant | Common Stock | 30k | $0.00 | $0 | | 06/06/2023 |
| 06/06/2023 | Akebia Therapeutics, Inc. | AKBA | Grant | Stock Option (Right to buy) | 45k | $1.20 | $54k | | 06/06/2023 |
| 09/15/2022 | Spero Therapeutics, Inc. | SPRO | Grant | Common Stock | 15k | $0.00 | $0 | | 09/15/2022 |
| 08/11/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | Grant | Restricted stock units | 6.9k | $0.00 | $0 | | 08/11/2022 |
| 08/11/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | Grant | Stock option (right to buy) | 37.9k | $25.99 | $986.2k | | 08/11/2022 |
| 06/08/2022 | Protara Therapeutics, Inc. | PRTO | Grant | Stock Option (Right to Buy) | 10k | $3.50 | $35k | | 06/08/2022 |
| 06/08/2022 | Akebia Therapeutics, Inc. | AKBA | Grant | Common Stock | 13.7k | $0.00 | $0 | | 06/08/2022 |
| 06/08/2022 | Akebia Therapeutics, Inc. | AKBA | Grant | Stock Option (Right to buy) | 20.1k | $0.45 | $9k | | 06/08/2022 |
| 12/28/2021 | Dicerna Pharmaceuticals Inc | DRNA | Disposition | Director Stock Option (Right to Buy) | 15k | $30.47 | $457k | | 12/28/2021 |
| 12/28/2021 | Dicerna Pharmaceuticals Inc | DRNA | Other | Common Stock | 3.3k | $38.25 | $127.5k | | 12/28/2021 |
| 12/28/2021 | Dicerna Pharmaceuticals Inc | DRNA | Disposition | Restricted Stock Units | 3.3k | $0.00 | $0 | | 12/28/2021 |
| 12/28/2021 | Dicerna Pharmaceuticals Inc | DRNA | Disposition | Director Stock Option (Right to Buy) | 25k | $14.76 | $369k | | 12/28/2021 |
| 12/28/2021 | Dicerna Pharmaceuticals Inc | DRNA | Disposition | Director Stock Option (Right to Buy) | 25k | $15.44 | $386k | | 12/28/2021 |
| 12/28/2021 | Dicerna Pharmaceuticals Inc | DRNA | Disposition | Director Stock Option (Right to Buy) | 15k | $21.61 | $324.2k | | 12/28/2021 |
| 08/17/2021 | Spero Therapeutics, Inc. | SPRO | Grant | Stock Option (right to buy) | 7.5k | $13.69 | $102.7k | | 08/17/2021 |
| 06/09/2021 | Protara Therapeutics, Inc. | PRTO | Grant | Stock Option (Right to Buy) | 10k | $10.51 | $105.1k | | 06/09/2021 |
| 06/03/2021 | Dicerna Pharmaceuticals Inc | DRNA | Grant | Director Stock Option (Right to Buy) | 15k | $30.47 | $457k | | 06/03/2021 |
| 06/03/2021 | Dicerna Pharmaceuticals Inc | DRNA | Grant | Restricted Stock Units | 3.3k | $0.00 | $0 | | 06/03/2021 |
| 06/03/2021 | Dicerna Pharmaceuticals Inc | DRNA | Exercise | Restricted Stock Units | 3.3k | $0.00 | $0 | | 06/03/2021 |
| 06/02/2021 | Akebia Therapeutics, Inc. | AKBA | Grant | Stock Option (Right to buy) | 20.1k | $3.37 | $67.7k | | 06/02/2021 |
| 06/02/2021 | Akebia Therapeutics, Inc. | AKBA | Grant | Common Stock | 13.7k | $0.00 | $0 | | 06/02/2021 |
| 01/29/2021 | Protara Therapeutics, Inc. | PRTO | Grant | Stock Option (Right to Buy) | 3.8k | $17.98 | $67.4k | | 01/29/2021 |
| 01/29/2021 | Protara Therapeutics, Inc. | PRTO | Grant | Stock Option (Right to Buy) | 18k | $17.98 | $323.6k | | 01/29/2021 |
| 01/04/2021 | Spero Therapeutics, Inc. | SPRO | Grant | Stock Option (right to buy) | 2.6k | $17.93 | $47.1k | | 01/04/2021 |
| 10/27/2020 | Spero Therapeutics, Inc. | SPRO | Grant | Stock Option (right to buy) | 7.5k | $13.52 | $101.4k | | 10/27/2020 |
| 06/15/2020 | Dicerna Pharmaceuticals Inc | DRNA | Grant | Restricted Stock Units | 3.3k | $0.00 | $0 | | 06/15/2020 |
| 06/15/2020 | Dicerna Pharmaceuticals Inc | DRNA | Grant | Director Stock Option (Right to Buy) | 15k | $21.61 | $324.2k | | 06/15/2020 |
| 06/08/2020 | Akebia Therapeutics, Inc. | AKBA | Sale | Common Stock | 4.6k | $12.10 | $55.3k | | 06/05/2020 |
| 06/05/2020 | Akebia Therapeutics, Inc. | AKBA | Grant | Stock Option (Right to buy) | 20.1k | $11.96 | $240.4k | | 06/05/2020 |
| 06/05/2020 | Akebia Therapeutics, Inc. | AKBA | Grant | Common Stock | 13.7k | $0.00 | $0 | | 06/05/2020 |
| 11/20/2019 | Akebia Therapeutics, Inc. | AKBA | Purchase | Common Stock | 15k | $3.52 | $52.8k | | 11/20/2019 |
| 06/20/2019 | Dicerna Pharmaceuticals Inc | DRNA | Grant | Director Stock Option (right to buy) | 25k | $15.44 | $386k | | 06/20/2019 |
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