| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 08/04/2023 | McDermott Wendy | VP, Human Resources | Purchase | Common Stock | 6k | $1.84 | $11k | | 08/04/2023 |
| 06/29/2023 | COATS LONNEL | CEO | Purchase | Common Stock | 10k | $2.16 | $21.6k | | 06/29/2023 |
| 06/05/2023 | Artal International S.C.A. | 10% Owner | Purchase | Common Stock | 27.8M | $2.60 | $72.2M | See Footnotes | 06/05/2023 |
| 04/28/2023 | Swain Judith L | Director | Grant | Restricted Stock Units | 8k | $0.00 | $0 | | 04/28/2023 |
| 04/28/2023 | Swain Judith L | Director | Grant | Stock Option (Right to Buy) | 12.7k | $2.36 | $29.9k | | 04/28/2023 |
| 04/28/2023 | LEFKOWITZ ROBERT J MD | Director | Grant | Restricted Stock Units | 8k | $0.00 | $0 | | 04/28/2023 |
| 04/28/2023 | LEFKOWITZ ROBERT J MD | Director | Grant | Stock Option (Right to Buy) | 12.7k | $2.36 | $29.9k | | 04/28/2023 |
| 04/28/2023 | NIES ALAN S | Director | Grant | Restricted Stock Units | 8k | $0.00 | $0 | | 04/28/2023 |
| 04/28/2023 | NIES ALAN S | Director | Grant | Stock Option (Right to Buy) | 12.7k | $2.36 | $29.9k | | 04/28/2023 |
| 04/28/2023 | DEBBANE RAYMOND | Director | Grant | Restricted Stock Units | 8k | $0.00 | $0 | | 04/28/2023 |
| 04/28/2023 | DEBBANE RAYMOND | Director | Grant | Stock Option (Right to Buy) | 12.7k | $2.36 | $29.9k | | 04/28/2023 |
| 04/28/2023 | Amouyal Philippe | Director | Grant | Restricted Stock Units | 8k | $0.00 | $0 | | 04/28/2023 |
| 04/28/2023 | Amouyal Philippe | Director | Grant | Stock Option (Right to Buy) | 12.7k | $2.36 | $29.9k | | 04/28/2023 |
| 04/28/2023 | BARKER SAM L | Director | Grant | Restricted Stock Units | 8k | $0.00 | $0 | | 04/28/2023 |
| 04/28/2023 | BARKER SAM L | Director | Grant | Stock Option (Right to Buy) | 12.7k | $2.36 | $29.9k | | 04/28/2023 |
| 02/28/2023 | WADE JEFFREY L | President and CFO | Payment of Exercise | Common Stock | 30.3k | $2.17 | $65.7k | | 02/28/2023 |
| 02/28/2023 | WADE JEFFREY L | President and CFO | Exercise | Restricted Stock Units | 30.5k | $0.00 | $0 | | 02/28/2023 |
| 02/28/2023 | WADE JEFFREY L | President and CFO | Exercise | Restricted Stock Units | 11.2k | $0.00 | $0 | | 02/28/2023 |
| 02/28/2023 | WADE JEFFREY L | President and CFO | Exercise | Restricted Stock Units | 37.3k | $0.00 | $0 | | 02/28/2023 |
| 02/28/2023 | MAIN ALAN J | EVP, Innov & Chem Sciences | Payment of Exercise | Common Stock | 20.9k | $2.17 | $45.5k | | 02/28/2023 |
| 02/28/2023 | MAIN ALAN J | EVP, Innov & Chem Sciences | Exercise | Restricted Stock Units | 23.3k | $0.00 | $0 | | 02/28/2023 |
| 02/28/2023 | MAIN ALAN J | EVP, Innov & Chem Sciences | Exercise | Restricted Stock Units | 9k | $0.00 | $0 | | 02/28/2023 |
| 02/28/2023 | MAIN ALAN J | EVP, Innov & Chem Sciences | Exercise | Restricted Stock Units | 25.7k | $0.00 | $0 | | 02/28/2023 |
| 02/28/2023 | COATS LONNEL | CEO | Payment of Exercise | Common Stock | 51k | $2.17 | $110.6k | | 02/28/2023 |
| 02/28/2023 | COATS LONNEL | CEO | Exercise | Restricted Stock Units | 84.6k | $0.00 | $0 | | 02/28/2023 |
| 02/28/2023 | COATS LONNEL | CEO | Exercise | Restricted Stock Units | 33.3k | $0.00 | $0 | | 02/28/2023 |
| 02/28/2023 | COATS LONNEL | CEO | Exercise | Restricted Stock Units | 91.4k | $0.00 | $0 | | 02/28/2023 |
| 02/28/2023 | Crum Brian T | SVP, General Counsel & Secr. | Payment of Exercise | Common Stock | 20.5k | $2.17 | $44.6k | | 02/28/2023 |
| 02/28/2023 | Crum Brian T | SVP, General Counsel & Secr. | Exercise | Restricted Stock Units | 21k | $0.00 | $0 | | 02/28/2023 |
| 02/28/2023 | Crum Brian T | SVP, General Counsel & Secr. | Exercise | Restricted Stock Units | 8.8k | $0.00 | $0 | | 02/28/2023 |
| 02/28/2023 | Crum Brian T | SVP, General Counsel & Secr. | Exercise | Restricted Stock Units | 26.1k | $0.00 | $0 | | 02/28/2023 |
| 02/28/2023 | Granowitz Craig B | SVP, Chief Medical Officer | Payment of Exercise | Common Stock | 12.7k | $2.17 | $27.6k | | 02/28/2023 |
| 02/28/2023 | Granowitz Craig B | SVP, Chief Medical Officer | Exercise | Restricted Stock Units | 27.9k | $0.00 | $0 | | 02/28/2023 |
| 02/28/2023 | Alexander Kristen | VP, Finance and Accounting | Payment of Exercise | Common Stock | 5.3k | $2.17 | $11.6k | | 02/28/2023 |
| 02/28/2023 | Alexander Kristen | VP, Finance and Accounting | Exercise | Restricted Stock Units | 5.4k | $0.00 | $0 | | 02/28/2023 |
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