| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 03/08/2018 | PAGLIA LOUIS J | Director | Disposition | Common Stock | 3.1k | $0.00 | $0 | | 03/08/2018 |
| 03/08/2018 | PAGLIA LOUIS J | Director | Disposition | Restricted Stock Units | 5.5k | $0.00 | $0 | | 03/08/2018 |
| 03/08/2018 | PAGLIA LOUIS J | Director | Disposition | Non-Qualified Stock Option | 26.8k | $44.51 | $1.2M | | 03/08/2018 |
| 03/08/2018 | Germano Geno J | Director | Disposition | Restricted Stock Units | 5.5k | $0.00 | $0 | | 03/08/2018 |
| 03/08/2018 | Germano Geno J | Director | Disposition | Non-Qualified Stock Option | 21.7k | $55.04 | $1.2M | | 03/08/2018 |
| 03/08/2018 | DENNER ALEXANDER J | Director | Disposition | Common Stock | 5k | $0.00 | $0 | | 03/08/2018 |
| 03/08/2018 | DENNER ALEXANDER J | Director | Disposition | Common Stock | 1.2M | $0.00 | $0 | See footnote | 03/08/2018 |
| 03/08/2018 | DENNER ALEXANDER J | Director | Disposition | Restricted Stock Units | 5.5k | $0.00 | $0 | | 03/08/2018 |
| 03/08/2018 | DENNER ALEXANDER J | Director | Disposition | Non-Qualified Stock Option | 26.8k | $44.51 | $1.2M | | 03/08/2018 |
| 03/08/2018 | Posner Brian S | Director | Disposition | Common Stock | 6.7k | $0.00 | $0 | | 03/08/2018 |
| 03/08/2018 | Posner Brian S | Director | Disposition | Restricted Stock Units | 6.4k | $0.00 | $0 | | 03/08/2018 |
| 03/08/2018 | Posner Brian S | Director | Disposition | Non-Qualified Stock Option | 3k | $44.51 | $132.6k | | 03/08/2018 |
| 03/08/2018 | Posner Brian S | Director | Disposition | Non-Qualified Stock Option | 26.8k | $44.51 | $1.2M | | 03/08/2018 |
| 03/08/2018 | Cox John | CEO | Disposition | Common Stock | 185.1k | $0.00 | $0 | | 03/08/2018 |
| 03/08/2018 | Cox John | CEO | Disposition | Restricted Stock Units | 136.4k | $0.00 | $0 | | 03/08/2018 |
| 03/08/2018 | Cox John | CEO | Disposition | Restricted Stock Units | 48.7k | $0.00 | $0 | | 03/08/2018 |
| 03/08/2018 | Cox John | CEO | Disposition | Non-Qualified Stock Option | 48.2k | $7.82 | $377.2k | | 03/08/2018 |
| 03/08/2018 | Cox John | CEO | Disposition | Non-Qualified Stock Option | 387.4k | $44.51 | $17.2M | | 03/08/2018 |
| 03/08/2018 | Cox John | CEO | Disposition | Non-Qualified Stock Option | 193.7k | $44.51 | $8.6M | | 03/08/2018 |
| 03/08/2018 | Harris Timothy J.R. | EVP, R & D | Disposition | Common Stock | 838.9492 | $0.00 | $0 | | 03/08/2018 |
| 03/08/2018 | Harris Timothy J.R. | EVP, R & D | Disposition | Restricted Stock Units | 11.3k | $0.00 | $0 | | 03/08/2018 |
| 03/08/2018 | Harris Timothy J.R. | EVP, R & D | Disposition | Restricted Stock Units | 40.9k | $0.00 | $0 | | 03/08/2018 |
| 03/08/2018 | Harris Timothy J.R. | EVP, R & D | Disposition | Non-Qualified Stock Option | 34.6k | $56.34 | $1.9M | | 03/08/2018 |
| 03/08/2018 | Harris Timothy J.R. | EVP, R & D | Disposition | Non-Qualified Stock Option | 33.8k | $56.34 | $1.9M | | 03/08/2018 |
| 03/08/2018 | Greene John | EVP, CFO and Treasurer | Disposition | Common Stock | 6k | $0.00 | $0 | | 03/08/2018 |
| 03/08/2018 | Greene John | EVP, CFO and Treasurer | Disposition | Restricted Stock Units | 14.2k | $0.00 | $0 | | 03/08/2018 |
| 03/08/2018 | Greene John | EVP, CFO and Treasurer | Disposition | Restricted Stock Units | 42.7k | $0.00 | $0 | | 03/08/2018 |
| 03/08/2018 | Greene John | EVP, CFO and Treasurer | Disposition | Non-Qualified Stock Option | 113.2k | $44.51 | $5M | | 03/08/2018 |
| 03/08/2018 | Greene John | EVP, CFO and Treasurer | Disposition | Non-Qualified Stock Option | 56.6k | $44.51 | $2.5M | | 03/08/2018 |
| 03/08/2018 | Vivaldi Coelho Rogerio | EVP, Chief Global Therapeutics | Disposition | Restricted Stock Units | 14.2k | $0.00 | $0 | | 03/08/2018 |
| 03/08/2018 | Vivaldi Coelho Rogerio | EVP, Chief Global Therapeutics | Disposition | Restricted Stock Units | 42.7k | $0.00 | $0 | | 03/08/2018 |
| 03/08/2018 | Vivaldi Coelho Rogerio | EVP, Chief Global Therapeutics | Disposition | Non-Qualified Stock Option | 113.2k | $44.51 | $5M | | 03/08/2018 |
| 03/08/2018 | Vivaldi Coelho Rogerio | EVP, Chief Global Therapeutics | Disposition | Non-Qualified Stock Option | 56.6k | $44.51 | $2.5M | | 03/08/2018 |
| 03/08/2018 | Vivaldi Coelho Rogerio | EVP, Chief Global Therapeutics | Disposition | Common Stock | 5.8k | $0.00 | $0 | | 03/08/2018 |
| 03/08/2018 | Protopapas Anna | Director | Disposition | Common Stock | 1.1k | $0.00 | $0 | | 03/08/2018 |
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