| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 06/08/2023 | Cox Russell J. | Director | Grant | Stock Option (Right to Buy) | 35k | $1.26 | $44.1k | | 06/08/2023 |
| 06/08/2023 | Daniel Thomas O | Director | Grant | Stock Option (Right to Buy) | 35k | $1.26 | $44.1k | | 06/08/2023 |
| 06/08/2023 | Burow Kristina | Director | Grant | Stock Option (Right to Buy) | 35k | $1.26 | $44.1k | | 06/08/2023 |
| 06/08/2023 | GALA RENEE D | Director | Grant | Stock Option (Right to Buy) | 35k | $1.26 | $44.1k | | 06/08/2023 |
| 06/08/2023 | Milligan Sandra | Director | Grant | Stock Option (Right to Buy) | 35k | $1.26 | $44.1k | | 06/08/2023 |
| 05/05/2023 | Aranda Richard | Chief Medical Officer | Disposition | Stock Option (Right to Buy) | 45k | $22.10 | $994.5k | | 05/05/2023 |
| 05/05/2023 | Aranda Richard | Chief Medical Officer | Disposition | Stock Option (Right to Buy) | 13.8k | $16.40 | $225.5k | | 05/05/2023 |
| 05/05/2023 | Aranda Richard | Chief Medical Officer | Disposition | Stock Option (Right to Buy) | 34.2k | $14.55 | $497.2k | | 05/05/2023 |
| 05/05/2023 | Aranda Richard | Chief Medical Officer | Disposition | Stock Option (Right to Buy) | 60k | $9.79 | $587.4k | | 05/05/2023 |
| 05/05/2023 | Aranda Richard | Chief Medical Officer | Disposition | Stock Option (Right to Buy) | 30k | $8.47 | $254.1k | | 05/05/2023 |
| 05/05/2023 | Aranda Richard | Chief Medical Officer | Disposition | Stock Option (Right to Buy) | 190k | $11.94 | $2.3M | | 05/05/2023 |
| 05/05/2023 | Aranda Richard | Chief Medical Officer | Grant | Stock Option (Right to Buy) | 30k | $0.00 | $0 | | 05/05/2023 |
| 05/05/2023 | Aranda Richard | Chief Medical Officer | Grant | Stock Option (Right to Buy) | 9.2k | $0.00 | $0 | | 05/05/2023 |
| 05/05/2023 | Aranda Richard | Chief Medical Officer | Grant | Stock Option (Right to Buy) | 22.8k | $0.00 | $0 | | 05/05/2023 |
| 05/05/2023 | Aranda Richard | Chief Medical Officer | Grant | Stock Option (Right to Buy) | 40k | $0.00 | $0 | | 05/05/2023 |
| 05/05/2023 | Aranda Richard | Chief Medical Officer | Grant | Stock Option (Right to Buy) | 20k | $0.00 | $0 | | 05/05/2023 |
| 05/05/2023 | Aranda Richard | Chief Medical Officer | Grant | Stock Option (Right to Buy) | 126.7k | $0.00 | $0 | | 05/05/2023 |
| 05/05/2023 | Peterson Caryn | EVP, Regulatory Affairs | Grant | Stock Option (Right to Buy) | 126.7k | $0.00 | $0 | | 05/05/2023 |
| 05/05/2023 | Peterson Caryn | EVP, Regulatory Affairs | Disposition | Stock Option (Right to Buy) | 13.8k | $16.40 | $225.5k | | 05/05/2023 |
| 05/05/2023 | Peterson Caryn | EVP, Regulatory Affairs | Disposition | Stock Option (Right to Buy) | 34.2k | $14.55 | $497.2k | | 05/05/2023 |
| 05/05/2023 | Peterson Caryn | EVP, Regulatory Affairs | Disposition | Stock Option (Right to Buy) | 28.2k | $9.79 | $276.6k | | 05/05/2023 |
| 05/05/2023 | Peterson Caryn | EVP, Regulatory Affairs | Disposition | Stock Option (Right to Buy) | 31.8k | $8.49 | $269.6k | | 05/05/2023 |
| 05/05/2023 | Peterson Caryn | EVP, Regulatory Affairs | Disposition | Stock Option (Right to Buy) | 190k | $11.94 | $2.3M | | 05/05/2023 |
| 05/05/2023 | Peterson Caryn | EVP, Regulatory Affairs | Grant | Stock Option (Right to Buy) | 32.3k | $0.00 | $0 | | 05/05/2023 |
| 05/05/2023 | Peterson Caryn | EVP, Regulatory Affairs | Grant | Stock Option (Right to Buy) | 9.2k | $0.00 | $0 | | 05/05/2023 |
| 05/05/2023 | Peterson Caryn | EVP, Regulatory Affairs | Grant | Stock Option (Right to Buy) | 22.8k | $0.00 | $0 | | 05/05/2023 |
| 05/05/2023 | Peterson Caryn | EVP, Regulatory Affairs | Grant | Stock Option (Right to Buy) | 18.8k | $0.00 | $0 | | 05/05/2023 |
| 05/05/2023 | Peterson Caryn | EVP, Regulatory Affairs | Disposition | Stock Option (Right to Buy) | 48.5k | $22.10 | $1.1M | | 05/05/2023 |
| 05/05/2023 | Peterson Caryn | EVP, Regulatory Affairs | Grant | Stock Option (Right to Buy) | 21.2k | $0.00 | $0 | | 05/05/2023 |
| 05/05/2023 | Giraudo Bryan | COO/CFO | Grant | Stock Option (Right to Buy) | 176.7k | $0.00 | $0 | | 05/05/2023 |
| 05/05/2023 | Giraudo Bryan | COO/CFO | Grant | Stock Option (Right to Buy) | 100k | $0.00 | $0 | | 05/05/2023 |
| 05/05/2023 | Giraudo Bryan | COO/CFO | Grant | Stock Option (Right to Buy) | 60k | $0.00 | $0 | | 05/05/2023 |
| 05/05/2023 | Giraudo Bryan | COO/CFO | Grant | Stock Option (Right to Buy) | 47.7k | $0.00 | $0 | | 05/05/2023 |
| 05/05/2023 | Giraudo Bryan | COO/CFO | Grant | Stock Option (Right to Buy) | 96.7k | $0.00 | $0 | | 05/05/2023 |
| 05/05/2023 | Giraudo Bryan | COO/CFO | Disposition | Stock Option (Right to Buy) | 265k | $11.94 | $3.2M | | 05/05/2023 |
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