| Date | Name | Symbol | Type | Security | Shares | Price | Value | Ownership | Reported |
| 08/09/2023 | RHYTHM PHARMACEUTICALS, INC. | RYTM | Exercise | Stock Option (Right to Buy) | 1.7k | $6.80 | $11.7k | | 08/07/2023 |
| 08/09/2023 | RHYTHM PHARMACEUTICALS, INC. | RYTM | Sale | Common Stock | 1.7k | $24.66 | $42.4k | | 08/07/2023 |
| 08/07/2023 | RHYTHM PHARMACEUTICALS, INC. | RYTM | Exercise | Stock Option (Right to Buy) | 8.6k | $6.80 | $58.4k | | 08/07/2023 |
| 08/07/2023 | RHYTHM PHARMACEUTICALS, INC. | RYTM | Sale | Common Stock | 11.2k | $24.18 | $271.3k | | 08/07/2023 |
| 02/14/2023 | RHYTHM PHARMACEUTICALS, INC. | RYTM | Sale | Common Stock | 635 | $26.87 | $17.1k | | 02/11/2023 |
| 02/11/2023 | RHYTHM PHARMACEUTICALS, INC. | RYTM | Exercise | Restricted Stock Units | 2k | $0.00 | $0 | | 02/11/2023 |
| 02/09/2023 | RHYTHM PHARMACEUTICALS, INC. | RYTM | Sale | Common Stock | 1.2k | $27.51 | $33.1k | | 02/09/2023 |
| 02/15/2022 | RHYTHM PHARMACEUTICALS, INC. | RYTM | Sale | Common Stock | 722 | $6.10 | $4.4k | | 02/11/2022 |
| 02/11/2022 | RHYTHM PHARMACEUTICALS, INC. | RYTM | Exercise | Restricted Stock Units | 2k | $0.00 | $0 | | 02/11/2022 |
| 02/09/2022 | RHYTHM PHARMACEUTICALS, INC. | RYTM | Grant | Restricted Stock Units | 13.8k | $0.00 | $0 | | 02/09/2022 |
| 02/09/2022 | RHYTHM PHARMACEUTICALS, INC. | RYTM | Grant | Stock Option (Right to Buy) | 82.5k | $6.80 | $561k | | 02/09/2022 |
| 11/09/2020 | RHYTHM PHARMACEUTICALS, INC. | RYTM | Grant | Stock Option (Right to Buy) | 100k | $24.29 | $2.4M | | 11/09/2020 |