| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 10/05/2023 | Wilderotter Mary Agnes | Director | Grant | Common Stock | 2.1k | $0.00 | $0 | | 10/05/2023 |
| 10/05/2023 | Bishop Hans Edgar | Director | Grant | Common Stock | 6.9k | $0.00 | $0 | | 10/05/2023 |
| 07/05/2023 | Wilderotter Mary Agnes | Director | Grant | Common Stock | 1.2k | $0.00 | $0 | | 07/05/2023 |
| 07/05/2023 | Bishop Hans Edgar | Director | Grant | Common Stock | 4.2k | $0.00 | $0 | | 07/05/2023 |
| 06/08/2023 | Yang Patrick Y | Director | Grant | Stock Option (Right to Buy) | 65k | $6.70 | $435.5k | | 06/08/2023 |
| 06/08/2023 | Cole Douglas G. | Director | Grant | Stock Option (Right to Buy) | 65k | $6.70 | $435.5k | | 06/08/2023 |
| 06/08/2023 | REICIN ALISE | Director | Grant | Stock Option (Right to Buy) | 65k | $6.70 | $435.5k | | 06/08/2023 |
| 06/08/2023 | Bilenker Joshua H. | Director | Grant | Stock Option (Right to Buy) | 65k | $6.70 | $435.5k | | 06/08/2023 |
| 06/08/2023 | Seitz Michelle | Director | Grant | Stock Option (Right to Buy) | 65k | $6.70 | $435.5k | | 06/08/2023 |
| 06/08/2023 | Wilderotter Mary Agnes | Director | Grant | Stock Option (Right to Buy) | 65k | $6.70 | $435.5k | | 06/08/2023 |
| 06/08/2023 | NELSEN ROBERT | 10% Owner | Grant | Stock Option (Right to Buy) | 65k | $6.70 | $435.5k | | 06/08/2023 |
| 06/08/2023 | Bishop Hans Edgar | Director | Grant | Stock Option (Right to Buy) | 65k | $6.70 | $435.5k | | 06/08/2023 |
| 06/07/2023 | Flagship Ventures Fund V General Partner LLC | 10% Owner | Sale | Common Stock | 177.2k | $6.24 | $1.1M | By Flagship Ventures Fund V, L.P. | 06/06/2023 |
| 06/07/2023 | Flagship Ventures Fund V General Partner LLC | 10% Owner | Sale | Common Stock | 22.8k | $6.24 | $142k | By Flagship V VentureLabs Rx Fund, L.P. | 06/06/2023 |
| 06/06/2023 | Flagship Ventures Fund V General Partner LLC | 10% Owner | Sale | Common Stock | 181.5k | $6.31 | $1.1M | By Flagship Ventures Fund V, L.P. | 06/06/2023 |
| 06/06/2023 | Flagship Ventures Fund V General Partner LLC | 10% Owner | Sale | Common Stock | 22.3k | $6.31 | $140.6k | By Flagship V VentureLabs Rx Fund, L.P. | 06/06/2023 |
| 05/26/2023 | Flagship Ventures Fund V General Partner LLC | 10% Owner | Sale | Common Stock | 72.7k | $6.23 | $452.5k | By Flagship Ventures Fund V, L.P. | 05/24/2023 |
| 05/26/2023 | Flagship Ventures Fund V General Partner LLC | 10% Owner | Sale | Common Stock | 9.3k | $6.23 | $58.1k | By Flagship V VentureLabs Rx Fund, L.P. | 05/24/2023 |
| 05/25/2023 | Flagship Ventures Fund V General Partner LLC | 10% Owner | Sale | Common Stock | 102.2k | $6.35 | $649.5k | By Flagship Ventures Fund V, L.P. | 05/24/2023 |
| 05/25/2023 | Flagship Ventures Fund V General Partner LLC | 10% Owner | Sale | Common Stock | 13.1k | $6.35 | $83.4k | By Flagship V VentureLabs Rx Fund, L.P. | 05/24/2023 |
| 05/24/2023 | Flagship Ventures Fund V General Partner LLC | 10% Owner | Sale | Common Stock | 308.3k | $6.57 | $2M | By Flagship Ventures Fund V, L.P. | 05/24/2023 |
| 05/24/2023 | Flagship Ventures Fund V General Partner LLC | 10% Owner | Sale | Common Stock | 39.6k | $6.57 | $259.9k | By Flagship V VentureLabs Rx Fund, L.P. | 05/24/2023 |
| 04/05/2023 | Wilderotter Mary Agnes | Director | Grant | Common Stock | 2.3k | $0.00 | $0 | | 04/05/2023 |
| 04/05/2023 | Bishop Hans Edgar | Director | Grant | Common Stock | 7.7k | $0.00 | $0 | | 04/05/2023 |
| 01/05/2023 | Bishop Hans Edgar | Director | Grant | Common Stock | 6.7k | $0.00 | $0 | | 01/05/2023 |
| 01/05/2023 | NELSEN ROBERT | 10% Owner | Grant | Common Stock | 536 | $0.00 | $0 | | 01/05/2023 |
| 10/05/2022 | Bishop Hans Edgar | Director | Grant | Common Stock | 4k | $0.00 | $0 | | 10/05/2022 |
| 10/05/2022 | NELSEN ROBERT | 10% Owner | Grant | Common Stock | 321 | $0.00 | $0 | | 10/05/2022 |
| 09/15/2022 | Cassidy Bernard J | EVP & General Counsel | Grant | Stock Option (Right to Buy) | 800k | $7.13 | $5.7M | | 09/15/2022 |
| 07/05/2022 | NELSEN ROBERT | 10% Owner | Grant | Common Stock | 266 | $0.00 | $0 | | 07/05/2022 |
| 07/05/2022 | Bishop Hans Edgar | Director | Grant | Common Stock | 3.3k | $0.00 | $0 | | 07/05/2022 |
| 06/13/2022 | MacDonald James J. | EVP & General Counsel | Exercise | Stock Option (Right to Buy) | 66.8k | $1.48 | $98.9k | | 06/13/2022 |
| 06/06/2022 | Bilenker Joshua H. | Director | Grant | Stock Option (Right to Buy) | 65k | $4.95 | $321.8k | | 06/06/2022 |
| 06/06/2022 | Cole Douglas G. | Director | Grant | Stock Option (Right to Buy) | 65k | $4.95 | $321.8k | | 06/06/2022 |
| 06/06/2022 | Seitz Michelle | Director | Grant | Stock Option (Right to Buy) | 65k | $4.95 | $321.8k | | 06/06/2022 |
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