| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 10/01/2013 | Cross Leland H | Senior V.P. | Disposition | Ordinary shares, par value $0.01 per share | 189.4k | $0.00 | $0 | | 09/30/2013 |
| 10/01/2013 | Howard Alvin D | Sr. V.P., Regulatory Affairs | Disposition | Ordinary shares, par value $0.01 per share | 84.2k | $0.00 | $0 | | 09/30/2013 |
| 10/01/2013 | Ellman Herman | Senior V.P., Clinical Devel. | Disposition | Ordinary shares, par value $0.01 per share | 165.8k | $0.00 | $0 | | 09/30/2013 |
| 10/01/2013 | Herendeen Paul | Exec. V.P. and CFO | Disposition | Ordinary shares, par value $0.01 per share | 94.9k | $0.00 | $0 | | 09/30/2013 |
| 10/01/2013 | Boissonneault Roger M | CEO & President | Disposition | Ordinary shares, par value $0.01 per share | 2.2M | $0.00 | $0 | | 09/30/2013 |
| 10/01/2013 | Boissonneault Roger M | CEO & President | Disposition | Ordinary shares, par value $0.01 per share | 300k | $0.00 | $0 | See footnote | 09/30/2013 |
| 10/01/2013 | BLOEM JAMES H | Director | Disposition | Ordinary shares, par value $0.01 per share | 24.2k | $0.00 | $0 | | 09/30/2013 |
| 10/01/2013 | KING JOHN A | Director | Disposition | Ordinary shares, par value $0.01 per share | 1.4M | $0.00 | $0 | By Roanzo Limited | 09/30/2013 |
| 10/01/2013 | Gilligan Claire A | Senior V.P., Quality | Disposition | Ordinary shares, par value $0.01 per share | 62.2k | $0.00 | $0 | | 09/30/2013 |
| 10/01/2013 | Gilligan Claire A | Senior V.P., Quality | Disposition | Ordinary shares, par value $0.01 per share | 28k | $0.00 | $0 | By Husband | 09/30/2013 |
| 10/01/2013 | Fuhrmann Rochelle | Senior V.P., Finance | Disposition | Ordinary shares, par value $0.01 per share | 41.1k | $0.00 | $0 | | 09/30/2013 |
| 10/01/2013 | Halstead Michael | Senior V.P., Corp. Development | Disposition | Ordinary shares, par value $0.01 per share | 36.4k | $0.00 | $0 | | 09/30/2013 |
| 10/01/2013 | Fenton Andrew | Senior V.P., CIO | Disposition | Ordinary shares, par value $0.01 per share | 92.8k | $0.00 | $0 | | 09/30/2013 |
| 10/01/2013 | Rodriguez Rama Francisco | Senior V.P., Tech. Operations | Disposition | Ordinary shares, par value $0.01 per share | 22.1k | $0.00 | $0 | | 09/30/2013 |
| 10/01/2013 | Sullivan Ryan T | VP, General Counsel & Secr. | Disposition | Ordinary shares, par value $0.01 per share | 18k | $0.00 | $0 | | 09/30/2013 |
| 09/30/2013 | Sullivan Ryan T | VP, General Counsel & Secr. | Disposition | Performance Restricted Share Units | 8.2k | $0.00 | $0 | | 09/30/2013 |
| 09/30/2013 | Sullivan Ryan T | VP, General Counsel & Secr. | Disposition | Option to purchase ordinary shares par value $0.01 per share | 2.2k | $2.02 | $4.4k | | 09/30/2013 |
| 09/30/2013 | Sullivan Ryan T | VP, General Counsel & Secr. | Disposition | Option to purchase ordinary shares par value $0.01 per share | 1.1k | $1.88 | $2k | | 09/30/2013 |
| 09/30/2013 | Sullivan Ryan T | VP, General Counsel & Secr. | Disposition | Option to purchase ordinary shares par value $0.01 per share | 6.6k | $16.06 | $106.2k | | 09/30/2013 |
| 09/30/2013 | Sullivan Ryan T | VP, General Counsel & Secr. | Disposition | Option to purchase ordinary shares par value $0.01 per share | 9k | $21.49 | $193.2k | | 09/30/2013 |
| 09/30/2013 | Sullivan Ryan T | VP, General Counsel & Secr. | Disposition | Option to purchase ordinary shares par value $0.01 per share | 15.7k | $13.35 | $210k | | 09/30/2013 |
| 09/30/2013 | Sullivan Ryan T | VP, General Counsel & Secr. | Disposition | Option to purchase ordinary shares par value $0.01 per share | 28.9k | $14.31 | $413k | | 09/30/2013 |
| 09/30/2013 | Vincze Leslie Stephan | SVP, Chief Compliance Officer | Disposition | Ordinary shares, par value $0.01 per share | 33k | $0.00 | $0 | | 09/30/2013 |
| 09/30/2013 | Rodriguez Rama Francisco | Senior V.P., Tech. Operations | Disposition | Option to purchase ordinary shares par value $0.01 per share | 13.7k | $13.35 | $182.6k | | 09/30/2013 |
| 09/30/2013 | Rodriguez Rama Francisco | Senior V.P., Tech. Operations | Disposition | Option to purchase ordinary shares par value $0.01 per share | 28.9k | $14.31 | $413k | | 09/30/2013 |
| 09/30/2013 | Rodriguez Rama Francisco | Senior V.P., Tech. Operations | Disposition | Option to purchase ordinary shares par value $0.01 per share | 15.4k | $19.71 | $304.1k | | 09/30/2013 |
| 09/30/2013 | Rodriguez Rama Francisco | Senior V.P., Tech. Operations | Disposition | Ordinary shares, par value $0.01 per share | 13.6k | $0.00 | $0 | | 09/30/2013 |
| 09/30/2013 | Rodriguez Rama Francisco | Senior V.P., Tech. Operations | Disposition | Option to purchase ordinary shares par value $0.01 per share | 16.6k | $11.61 | $192.6k | | 09/30/2013 |
| 09/30/2013 | Sullivan Ryan T | VP, General Counsel & Secr. | Disposition | Ordinary shares, par value $0.01 per share | 8.4k | $0.00 | $0 | | 09/30/2013 |
| 09/30/2013 | Rodriguez Rama Francisco | Senior V.P., Tech. Operations | Disposition | Performance Restricted Share Units | 13.2k | $0.00 | $0 | | 09/30/2013 |
| 09/30/2013 | Fenton Andrew | Senior V.P., CIO | Disposition | Performance Restricted Share Units | 15k | $0.00 | $0 | | 09/30/2013 |
| 09/30/2013 | Fenton Andrew | Senior V.P., CIO | Disposition | Option to purchase ordinary shares par value $0.01 per share | 10k | $3.73 | $37.3k | | 09/30/2013 |
| 09/30/2013 | Fenton Andrew | Senior V.P., CIO | Disposition | Option to purchase ordinary shares par value $0.01 per share | 9.6k | $6.37 | $61.3k | | 09/30/2013 |
| 09/30/2013 | Fenton Andrew | Senior V.P., CIO | Disposition | Option to purchase ordinary shares par value $0.01 per share | 17.3k | $2.02 | $35k | | 09/30/2013 |
| 09/30/2013 | Fenton Andrew | Senior V.P., CIO | Disposition | Option to purchase ordinary shares par value $0.01 per share | 9.1k | $16.06 | $145.8k | | 09/30/2013 |
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