| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 08/15/2023 | Jain Vivek | EVP, Global Operations | Exercise | Restricted Stock Unit (RSU) | 4.1k | $0.00 | $0 | | 08/15/2023 |
| 08/15/2023 | Jain Vivek | EVP, Global Operations | Payment of Exercise | Comm Stock - $.16-2/3 value | 2k | $181.32 | $368.7k | | 08/15/2023 |
| 08/01/2023 | ROCHE VINCENT | Chair & CEO | Sale | Comm Stock - $.16-2/3 value | 10k | $197.64 | $2M | | 08/01/2023 |
| 08/01/2023 | ROCHE VINCENT | Chair & CEO | Exercise | Non-Qualified Stock Option (right to buy) | 10k | $83.48 | $834.8k | | 08/01/2023 |
| 07/10/2023 | ROCHE VINCENT | Chair & CEO | Sale | Comm Stock - $.16-2/3 value | 10k | $185.91 | $1.9M | | 07/10/2023 |
| 07/10/2023 | ROCHE VINCENT | Chair & CEO | Exercise | Non-Qualified Stock Option (right to buy) | 10k | $83.48 | $834.8k | | 07/10/2023 |
| 06/08/2023 | ROCHE VINCENT | Chair & CEO | Sale | Comm Stock - $.16-2/3 value | 4.4k | $181.11 | $788.9k | | 06/08/2023 |
| 06/08/2023 | ROCHE VINCENT | Chair & CEO | Sale | Comm Stock - $.16-2/3 value | 20.6k | $181.02 | $3.7M | | 06/08/2023 |
| 06/08/2023 | ROCHE VINCENT | Chair & CEO | Exercise | Non-Qualified Stock Option (right to buy) | 4.4k | $83.48 | $363.6k | | 06/08/2023 |
| 06/08/2023 | ROCHE VINCENT | Chair & CEO | Exercise | Non-Qualified Stock Option (right to buy) | 20.6k | $91.13 | $1.9M | | 06/08/2023 |
| 04/03/2023 | ROCHE VINCENT | Chair & CEO | Grant | Restricted Stock Unit (RSU) | 26.6k | $0.00 | $0 | | 04/03/2023 |
| 04/03/2023 | ROCHE VINCENT | Chair & CEO | Grant | Performance-Based Restricted Stock Unit | 29.1k | $0.00 | $0 | | 04/03/2023 |
| 04/03/2023 | ROCHE VINCENT | Chair & CEO | Grant | Performance-Based Restricted Stock Unit | 42.9k | $0.00 | $0 | | 04/03/2023 |
| 04/03/2023 | Jain Vivek | EVP, Global Operations | Grant | Restricted Stock Unit (RSU) | 9.8k | $0.00 | $0 | | 04/03/2023 |
| 04/03/2023 | Jain Vivek | EVP, Global Operations | Grant | Performance-Based Restricted Stock Unit | 6.6k | $0.00 | $0 | | 04/03/2023 |
| 04/03/2023 | Jain Vivek | EVP, Global Operations | Grant | Performance-Based Restricted Stock Unit | 9.8k | $0.00 | $0 | | 04/03/2023 |
| 04/03/2023 | Mahendra-Rajah Prashanth | EVP, Finance & CFO | Grant | Restricted Stock Unit (RSU) | 10.4k | $0.00 | $0 | | 04/03/2023 |
| 04/03/2023 | Mahendra-Rajah Prashanth | EVP, Finance & CFO | Grant | Performance-Based Restricted Stock Unit | 7k | $0.00 | $0 | | 04/03/2023 |
| 04/03/2023 | Mahendra-Rajah Prashanth | EVP, Finance & CFO | Grant | Performance-Based Restricted Stock Unit | 10.5k | $0.00 | $0 | | 04/03/2023 |
| 04/03/2023 | Sondel Michael | CAO (principal acct. officer) | Grant | Restricted Stock Unit (RSU) | 1.8k | $0.00 | $0 | | 04/03/2023 |
| 04/03/2023 | Sondel Michael | CAO (principal acct. officer) | Grant | Performance-Based Restricted Stock Unit | 499 | $0.00 | $0 | | 04/03/2023 |
| 04/03/2023 | Sondel Michael | CAO (principal acct. officer) | Grant | Performance-Based Restricted Stock Unit | 804 | $0.00 | $0 | | 04/03/2023 |
| 04/03/2023 | Bryant Gregory M | EVP & Pres. Global Bus. Units | Grant | Restricted Stock Unit (RSU) | 14.9k | $0.00 | $0 | | 04/03/2023 |
| 04/03/2023 | Bryant Gregory M | EVP & Pres. Global Bus. Units | Grant | Performance-Based Restricted Stock Unit | 10k | $0.00 | $0 | | 04/03/2023 |
| 04/03/2023 | Bryant Gregory M | EVP & Pres. Global Bus. Units | Grant | Performance-Based Restricted Stock Unit | 15k | $0.00 | $0 | | 04/03/2023 |
| 04/03/2023 | Sacks Anelise Angelino | SVP, Chief Customer Officer | Grant | Restricted Stock Unit (RSU) | 9.3k | $0.00 | $0 | | 04/03/2023 |
| 04/03/2023 | Sacks Anelise Angelino | SVP, Chief Customer Officer | Grant | Performance-Based Restricted Stock Unit | 6.2k | $0.00 | $0 | | 04/03/2023 |
| 04/03/2023 | Sacks Anelise Angelino | SVP, Chief Customer Officer | Grant | Performance-Based Restricted Stock Unit | 9.4k | $0.00 | $0 | | 04/03/2023 |
| 03/21/2023 | Mahendra-Rajah Prashanth | EVP, Finance & CFO | Sale | Comm Stock - $.16-2/3 value | 8.8k | $189.00 | $1.7M | | 03/21/2023 |
| 03/21/2023 | Mahendra-Rajah Prashanth | EVP, Finance & CFO | Exercise | Non-Qualified Stock Option (right to buy) | 8.8k | $91.13 | $797.5k | | 03/21/2023 |
| 03/20/2023 | Mahendra-Rajah Prashanth | EVP, Finance & CFO | Exercise | Comm Stock - $.16-2/3 value | 26.2k | $0.00 | $0 | | 03/20/2023 |
| 03/20/2023 | Mahendra-Rajah Prashanth | EVP, Finance & CFO | Sale | Comm Stock - $.16-2/3 value | 26.2k | $187.01 | $4.9M | | 03/20/2023 |
| 03/20/2023 | Mahendra-Rajah Prashanth | EVP, Finance & CFO | Exercise | Non-Qualified Stock Option (right to buy) | 26.2k | $94.41 | $2.5M | | 03/20/2023 |
| 03/15/2023 | Mahendra-Rajah Prashanth | EVP, Finance & CFO | Payment of Exercise | Comm Stock - $.16-2/3 value | 861 | $182.93 | $157.5k | | 12/05/2022 |
| 03/15/2023 | Mahendra-Rajah Prashanth | EVP, Finance & CFO | Payment of Exercise | Comm Stock - $.16-2/3 value | 1.5k | $182.93 | $270.7k | | 12/05/2022 |
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