BROWN JAMES E [Rocket]

Date	Name	Symbol	Type	Security	Shares	Price	Value	Ownership	Reported
02/21/2023	DURECT CORP	DRRX	Grant	Stock Option (right to buy)	50.7k	$5.07	$256.9k		02/21/2023
02/21/2023	DURECT CORP	DRRX	Grant	Stock Option (right to buy)	200k	$5.07	$1M		02/21/2023
01/06/2022	DURECT CORP	DRRX	Grant	Stock Option (right to buy)	956.1k	$0.87	$832.8k		01/06/2022
01/15/2021	DURECT CORP	DRRX	Grant	Stock Option (right to buy)	209k	$2.03	$424.3k		01/15/2021
01/21/2020	DURECT CORP	DRRX	Grant	Incentive Stock Option (right to buy)	86.9k	$2.11	$183.3k		01/21/2020
01/21/2020	DURECT CORP	DRRX	Grant	Non-Qualified Stock Option (right to buy)	138.1k	$2.11	$291.5k		01/21/2020
01/23/2019	DURECT CORP	DRRX	Grant	Incentive Stock Option (right to buy)	53.9k	$0.58	$31.1k		01/23/2019
01/23/2019	DURECT CORP	DRRX	Grant	Non-Qualified Stock Option (right to buy)	221.8k	$0.58	$127.9k		01/23/2019
01/23/2019	DURECT CORP	DRRX	Grant	Non-Qualified Stock Option (right to buy)	96.1k	$0.58	$55.4k		01/23/2019
11/27/2018	DURECT CORP	DRRX	Purchase	Common Stock	400	$0.81	$324	by Brown 2006 Trust	11/27/2018
11/27/2018	DURECT CORP	DRRX	Purchase	Common Stock	900	$0.81	$730.4	by Brown 2006 Trust	11/27/2018
11/27/2018	DURECT CORP	DRRX	Purchase	Common Stock	200	$0.81	$162.3	by Brown 2006 Trust	11/27/2018
11/27/2018	DURECT CORP	DRRX	Purchase	Common Stock	400	$0.81	$325.4	by Brown 2006 Trust	11/27/2018
11/27/2018	DURECT CORP	DRRX	Purchase	Common Stock	200	$0.82	$163	by Brown 2006 Trust	11/27/2018
11/27/2018	DURECT CORP	DRRX	Purchase	Common Stock	500	$0.82	$407.9	by Brown 2006 Trust	11/27/2018
11/27/2018	DURECT CORP	DRRX	Purchase	Common Stock	100	$0.81	$80.5	by Brown 2006 Trust	11/27/2018
11/27/2018	DURECT CORP	DRRX	Purchase	Common Stock	700	$0.83	$580.7	by Brown 2006 Trust	11/27/2018
11/27/2018	DURECT CORP	DRRX	Purchase	Common Stock	6.1k	$0.81	$4.9k	by Brown 2006 Trust	11/27/2018
11/27/2018	DURECT CORP	DRRX	Purchase	Common Stock	200	$0.81	$161.8	by Brown 2006 Trust	11/27/2018
11/27/2018	DURECT CORP	DRRX	Purchase	Common Stock	300	$0.81	$241.9	by Brown 2006 Trust	11/27/2018
01/26/2018	DURECT CORP	DRRX	Grant	Non-Qualified Stock Option (right to buy)	162.3k	$1.24	$201.3k		01/26/2018
01/26/2018	DURECT CORP	DRRX	Grant	Non-Qualified Stock Option (right to buy)	188.2k	$1.24	$233.4k		01/26/2018
01/26/2018	DURECT CORP	DRRX	Grant	Incentive Stock Option (right to buy)	87.7k	$1.24	$108.7k		01/26/2018
01/09/2017	DURECT CORP	DRRX	Grant	Incentive Stock Option (right to buy)	91.9k	$1.31	$120.4k		01/09/2017
01/09/2017	DURECT CORP	DRRX	Grant	Non-Qualified Stock Option (right to buy)	133.1k	$1.31	$174.4k		01/09/2017
01/09/2017	DURECT CORP	DRRX	Grant	Non-Qualified Stock Option (right to buy)	145.7k	$1.31	$190.8k		01/09/2017