| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 03/17/2033 | Lee Phillip E | CFO | Grant | Stock Option (right to buy) | 410k | $0.78 | $319.8k | | 03/17/2023 |
| 03/17/2023 | Lee Phillip E | CFO | Grant | Common Stock | 45k | $0.00 | $0 | | 03/17/2023 |
| 03/17/2023 | Lee Phillip E | CFO | Grant | Common Stock | 56.7k | $0.00 | $0 | | 03/17/2023 |
| 03/17/2023 | Lee Phillip E | CFO | Grant | Stock Option (right to buy) | 205k | $0.78 | $159.9k | | 03/17/2023 |
| 03/17/2023 | Lee Phillip E | CFO | Grant | Common Stock | 45k | $0.00 | $0 | | 03/17/2023 |
| 03/17/2023 | Lee Phillip E | CFO | Grant | Common Stock | 56.7k | $0.00 | $0 | | 03/17/2023 |
| 03/17/2023 | Lee Phillip E | CFO | Grant | Common Stock | 90k | $0.00 | $0 | | 03/17/2023 |
| 03/17/2023 | Lee Phillip E | CFO | Grant | Stock Option (right to buy) | 205k | $0.78 | $159.9k | | 03/17/2023 |
| 03/17/2023 | Tucker Sean | SVP, Chief Scientific Officer | Grant | Common Stock | 45k | $0.00 | $0 | | 03/17/2023 |
| 03/17/2023 | Tucker Sean | SVP, Chief Scientific Officer | Grant | Common Stock | 54.2k | $0.00 | $0 | | 03/17/2023 |
| 03/17/2023 | Tucker Sean | SVP, Chief Scientific Officer | Grant | Common Stock | 90k | $0.00 | $0 | | 03/17/2023 |
| 03/17/2023 | Tucker Sean | SVP, Chief Scientific Officer | Grant | Stock Option (right to buy) | 205k | $0.78 | $159.9k | | 03/17/2023 |
| 03/17/2023 | Tucker Sean | SVP, Chief Scientific Officer | Grant | Stock Option (right to buy) | 410k | $0.78 | $319.8k | | 03/17/2023 |
| 03/17/2023 | Floroiu Cezar Andrei | President, Chief Exec Officer | Grant | Common Stock | 100k | $0.00 | $0 | | 03/17/2023 |
| 03/17/2023 | Floroiu Cezar Andrei | President, Chief Exec Officer | Grant | Common Stock | 92.7k | $0.00 | $0 | | 03/17/2023 |
| 03/17/2023 | Floroiu Cezar Andrei | President, Chief Exec Officer | Grant | Common Stock | 175k | $0.00 | $0 | | 03/17/2023 |
| 03/17/2023 | Floroiu Cezar Andrei | President, Chief Exec Officer | Grant | Stock Option (right to buy) | 400k | $0.78 | $312k | | 03/17/2023 |
| 03/17/2023 | Floroiu Cezar Andrei | President, Chief Exec Officer | Grant | Stock Option (right to buy) | 750k | $0.78 | $585k | | 03/17/2023 |
| 03/17/2023 | Cummings James F. | Chief Medical Officer | Grant | Common Stock | 45k | $0.00 | $0 | | 03/17/2023 |
| 03/17/2023 | Cummings James F. | Chief Medical Officer | Grant | Common Stock | 90k | $0.00 | $0 | | 03/17/2023 |
| 03/17/2023 | Cummings James F. | Chief Medical Officer | Grant | Stock Option (right to buy) | 205k | $0.78 | $159.9k | | 03/17/2023 |
| 03/17/2023 | Cummings James F. | Chief Medical Officer | Grant | Stock Option (right to buy) | 410k | $0.78 | $319.8k | | 03/17/2023 |
| 03/17/2023 | Cummings James F. | Chief Medical Officer | Grant | Common Stock | 59.4k | $0.00 | $0 | | 03/17/2023 |
| 03/17/2023 | Berg Edward B | SVP, General Counsel | Grant | Common Stock | 45k | $0.00 | $0 | | 03/17/2023 |
| 03/17/2023 | Berg Edward B | SVP, General Counsel | Grant | Common Stock | 52.6k | $0.00 | $0 | | 03/17/2023 |
| 03/17/2023 | Berg Edward B | SVP, General Counsel | Grant | Common Stock | 90k | $0.00 | $0 | | 03/17/2023 |
| 03/17/2023 | Berg Edward B | SVP, General Counsel | Grant | Stock Option (right to buy) | 205k | $0.78 | $159.9k | | 03/17/2023 |
| 03/17/2023 | Berg Edward B | SVP, General Counsel | Grant | Stock Option (right to buy) | 410k | $0.78 | $319.8k | | 03/17/2023 |
| 12/28/2022 | Watson W. Mark | Director | Purchase | Common Stock | 20k | $0.76 | $15.1k | | 12/28/2022 |
| 12/16/2022 | Lee Phillip E | CFO | Grant | Common Stock | 68.8k | $0.00 | $0 | | 12/16/2022 |
| 12/16/2022 | Lee Phillip E | CFO | Grant | Stock Option (Right to Buy) | 412.5k | $1.06 | $437.2k | | 12/16/2022 |
| 08/25/2022 | HERON ELAINE J | Director | Grant | Stock Option (right to buy) | 88.4k | $3.36 | $297.2k | | 08/25/2022 |
| 08/25/2022 | HERON ELAINE J | Director | Grant | Common Stock | 14.8k | $0.00 | $0 | | 08/25/2022 |
| 08/24/2022 | Yedid Robert A. | Director | Gift | Common Stock | 18.2k | $0.00 | $0 | | 08/24/2022 |
| 08/24/2022 | Yedid Robert A. | Director | Gift | Common Stock | 4k | $0.00 | $0 | | 08/24/2022 |
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