| Date | Name | Symbol | Type | Security | Shares | Price | Value | Ownership | Reported |
| 06/28/2023 | Trevi Therapeutics, Inc. | TRVI | Grant | Nonstatutory Stock Option (right to buy) | 30k | $2.27 | $68.1k | | 06/28/2023 |
| 03/06/2023 | CONCERT PHARMACEUTICALS, INC. | CNCE | Other | Common Stock | 80.6k | $0.00 | $0 | | 03/06/2023 |
| 03/06/2023 | CONCERT PHARMACEUTICALS, INC. | CNCE | Disposition | Common Stock | 57.8k | $0.00 | $0 | | 03/06/2023 |
| 03/06/2023 | CONCERT PHARMACEUTICALS, INC. | CNCE | Disposition | Performance Stock Units | 34.7k | $0.00 | $0 | | 03/06/2023 |
| 03/06/2023 | CONCERT PHARMACEUTICALS, INC. | CNCE | Disposition | Stock Option (Right to Buy) | 140k | $14.46 | $2M | | 03/06/2023 |
| 03/06/2023 | CONCERT PHARMACEUTICALS, INC. | CNCE | Disposition | Stock Option (Right to Buy) | 50k | $16.85 | $842.5k | | 03/06/2023 |
| 03/06/2023 | CONCERT PHARMACEUTICALS, INC. | CNCE | Disposition | Stock Option (Right to Buy) | 70k | $10.97 | $767.9k | | 03/06/2023 |
| 03/06/2023 | CONCERT PHARMACEUTICALS, INC. | CNCE | Disposition | Stock Option (Right to Buy) | 49.5k | $27.59 | $1.4M | | 03/06/2023 |
| 03/06/2023 | CONCERT PHARMACEUTICALS, INC. | CNCE | Disposition | Stock Option (Right to Buy) | 75k | $13.93 | $1M | | 03/06/2023 |
| 03/06/2023 | CONCERT PHARMACEUTICALS, INC. | CNCE | Disposition | Stock Option (Right to Buy) | 42.4k | $10.87 | $461.2k | | 03/06/2023 |
| 03/06/2023 | CONCERT PHARMACEUTICALS, INC. | CNCE | Disposition | Stock Option (Right to Buy) | 60.4k | $13.07 | $789.4k | | 03/06/2023 |
| 01/30/2023 | CONCERT PHARMACEUTICALS, INC. | CNCE | Sale | Common Stock | 10.1k | $8.35 | $84.4k | | 01/30/2023 |
| 01/06/2023 | CONCERT PHARMACEUTICALS, INC. | CNCE | Sale | Common Stock | 2.9k | $7.25 | $21k | | 01/06/2023 |
| 06/23/2022 | Trevi Therapeutics, Inc. | TRVI | Grant | Nonstatutory Stock Option (right to buy) | 20k | $2.27 | $45.4k | | 06/23/2022 |
| 06/23/2022 | Trevi Therapeutics, Inc. | TRVI | Grant | Nonstatutory Stock Option (right to buy) | 20k | $2.27 | $45.4k | | 06/23/2022 |
| 02/14/2022 | CONCERT PHARMACEUTICALS, INC. | CNCE | Sale | Common Stock | 3.8k | $3.09 | $11.6k | | 02/14/2022 |
| 01/28/2022 | CONCERT PHARMACEUTICALS, INC. | CNCE | Grant | Common Stock | 75.8k | $0.00 | $0 | | 01/28/2022 |
| 01/28/2022 | CONCERT PHARMACEUTICALS, INC. | CNCE | Grant | Common Stock | 34.7k | $0.00 | $0 | | 01/28/2022 |
| 01/05/2022 | CONCERT PHARMACEUTICALS, INC. | CNCE | Sale | Common Stock | 2.9k | $3.19 | $9.2k | | 01/05/2022 |
| 08/16/2021 | CONCERT PHARMACEUTICALS, INC. | CNCE | Sale | Common Stock | 8.1k | $3.28 | $26.5k | | 08/16/2021 |
| 06/16/2021 | Trevi Therapeutics, Inc. | TRVI | Grant | Nonstatutory Stock Option (right to buy) | 20k | $2.25 | $45k | | 06/16/2021 |
| 02/16/2021 | CONCERT PHARMACEUTICALS, INC. | CNCE | Sale | Common Stock | 3.8k | $7.32 | $27.5k | | 02/16/2021 |
| 01/05/2021 | CONCERT PHARMACEUTICALS, INC. | CNCE | Grant | Common Stock | 21.7k | $0.00 | $0 | | 01/05/2021 |
| 01/05/2021 | CONCERT PHARMACEUTICALS, INC. | CNCE | Grant | Stock Option (Right to Buy) | 60.4k | $13.07 | $789.4k | | 01/05/2021 |
| 08/17/2020 | CONCERT PHARMACEUTICALS, INC. | CNCE | Sale | Common Stock | 4.4k | $10.37 | $45.2k | | 08/17/2020 |
| 02/14/2020 | CONCERT PHARMACEUTICALS, INC. | CNCE | Grant | Common Stock | 28.2k | $0.00 | $0 | | 02/14/2020 |
| 02/14/2020 | CONCERT PHARMACEUTICALS, INC. | CNCE | Grant | Stock Option (Right to Buy) | 42.4k | $10.87 | $461.2k | | 02/14/2020 |
| 02/13/2020 | Trevi Therapeutics, Inc. | TRVI | Grant | Nonstatutory Stock Option (right to buy) | 23.7k | $5.50 | $130.3k | | 02/13/2020 |
| 08/15/2019 | CONCERT PHARMACEUTICALS, INC. | CNCE | Grant | Common Stock | 31.1k | $0.00 | $0 | | 08/15/2019 |
| 03/31/2019 | CONCERT PHARMACEUTICALS, INC. | CNCE | Payment of Exercise | Common Stock | 8.8k | $12.07 | $106.6k | | 03/31/2019 |
| 01/04/2019 | CONCERT PHARMACEUTICALS, INC. | CNCE | Grant | Employee Stock Option (right to buy) | 75k | $13.93 | $1M | | 01/04/2019 |
| 04/17/2018 | CONCERT PHARMACEUTICALS, INC. | CNCE | Sale | Common Stock | 10.6k | $20.18 | $213.5k | | 04/17/2018 |
| 03/31/2018 | CONCERT PHARMACEUTICALS, INC. | CNCE | Payment of Exercise | Common Stock | 4.4k | $22.90 | $101.2k | | 03/31/2018 |
| 03/31/2018 | CONCERT PHARMACEUTICALS, INC. | CNCE | Payment of Exercise | Common Stock | 4.4k | $22.90 | $101.2k | | 03/31/2018 |
| 01/04/2018 | CONCERT PHARMACEUTICALS, INC. | CNCE | Grant | Employee Stock Option (right to buy) | 49.5k | $27.59 | $1.4M | | 01/04/2018 |
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