| Date | Name | Symbol | Type | Security | Shares | Price | Value | Ownership | Reported |
| 08/10/2023 | Regulus Therapeutics Inc. | RGLS | Grant | Stock Option (Right to Buy) | 15k | $1.36 | $20.4k | | 08/10/2023 |
| 06/09/2022 | TREVENA INC | TRVN | Grant | Stock Option (Right to Buy) | 100k | $0.43 | $43k | | 06/09/2022 |
| 06/09/2022 | Regulus Therapeutics Inc. | RGLS | Grant | Stock Option (Right to Buy) | 90k | $0.27 | $24.3k | | 06/09/2022 |
| 06/14/2021 | Regulus Therapeutics Inc. | RGLS | Grant | Stock Option (Right to Buy) | 40k | $0.99 | $39.5k | | 06/14/2021 |
| 05/28/2021 | TREVENA INC | TRVN | Grant | Stock Option (Right to Buy) | 68.6k | $1.74 | $119.3k | | 05/28/2021 |
| 06/17/2020 | Regulus Therapeutics Inc. | RGLS | Grant | Stock Option (Right to Buy) | 23.2k | $0.88 | $20.5k | | 06/17/2020 |
| 05/13/2020 | TREVENA INC | TRVN | Grant | Stock Option (Right to Buy) | 64.1k | $1.05 | $67.3k | | 05/13/2020 |
| 02/20/2020 | Dermira, Inc. | DERM | Disposition | Common Stock | 6k | $18.75 | $112.5k | | 02/20/2020 |
| 02/20/2020 | Dermira, Inc. | DERM | Disposition | Director Stock Option (right to buy) | 10.3k | $16.00 | $165.3k | | 02/20/2020 |
| 02/20/2020 | Dermira, Inc. | DERM | Disposition | Director Stock Option (right to buy) | 10.3k | $28.82 | $298.1k | | 02/20/2020 |
| 02/20/2020 | Dermira, Inc. | DERM | Disposition | Director Stock Option (right to buy) | 6k | $28.01 | $168.1k | | 02/20/2020 |
| 02/20/2020 | Dermira, Inc. | DERM | Disposition | Director Stock Option (right to buy) | 6k | $9.95 | $59.7k | | 02/20/2020 |
| 02/20/2020 | Dermira, Inc. | DERM | Disposition | Director Stock Option (right to buy) | 6k | $9.38 | $56.3k | | 02/20/2020 |
| 02/20/2020 | Dermira, Inc. | DERM | Disposition | Restricted Stock Unit | 3k | $0.00 | $0 | | 02/20/2020 |
| 10/10/2019 | Regulus Therapeutics Inc. | RGLS | Grant | Stock Option (Right to Buy) | 46.5k | $0.64 | $29.8k | | 10/10/2019 |
| 06/12/2019 | Dermira, Inc. | DERM | Exercise | Common Stock | 3k | $0.00 | $0 | | 06/12/2019 |
| 06/04/2019 | Dermira, Inc. | DERM | Grant | Director Stock Option (right to buy) | 6k | $9.38 | $56.3k | | 06/04/2019 |
| 06/04/2019 | Dermira, Inc. | DERM | Grant | Restricted Stock Unit | 3k | $0.00 | $0 | | 06/04/2019 |
| 05/16/2019 | TREVENA INC | TRVN | Grant | Stock Option (Right to Buy) | 30k | $1.34 | $40.2k | | 05/16/2019 |
| 06/13/2018 | Dermira, Inc. | DERM | Exercise | Restricted Stock Unit | 3k | $0.00 | $0 | | 06/12/2018 |
| 06/12/2018 | Dermira, Inc. | DERM | Grant | Restricted Stock Unit | 3k | $0.00 | $0 | | 06/12/2018 |
| 06/12/2018 | Dermira, Inc. | DERM | Grant | Director Stock Option (right to buy) | 6k | $9.95 | $59.7k | | 06/12/2018 |
| 05/16/2018 | TREVENA INC | TRVN | Grant | Stock Option (Right to Buy) | 30k | $1.84 | $55.2k | | 05/16/2018 |
| 06/13/2017 | Dermira, Inc. | DERM | Grant | Director Stock Option (right to buy) | 6k | $28.01 | $168.1k | | 06/13/2017 |
| 06/13/2017 | Dermira, Inc. | DERM | Grant | Restricted Stock Unit | 3k | $0.00 | $0 | | 06/13/2017 |
| 05/17/2017 | TREVENA INC | TRVN | Grant | Stock Option (Right to Buy) | 15k | $3.08 | $46.2k | | 05/17/2017 |
| 06/21/2016 | Dermira, Inc. | DERM | Grant | Director Stock Option (right to buy) | 10.3k | $28.82 | $298.1k | | 06/21/2016 |
| 06/21/2016 | Dermira, Inc. | DERM | Grant | Director Stock Option (right to buy) | 10.3k | $28.82 | $298.1k | | 06/21/2016 |
| 05/18/2016 | TREVENA INC | TRVN | Grant | Director Stock Option (Right to Buy) | 15k | $6.98 | $104.7k | | 05/18/2016 |
| 04/15/2013 | HYPERION THERAPEUTICS INC | HPTX | Grant | Stock Option (right to buy) | 9.8k | $24.46 | $239.7k | | 04/15/2013 |