| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 10/03/2017 | MARKISON BRIAN A | Director | Disposition | Common Stock | 5.5k | $0.00 | $0 | | 10/03/2017 |
| 10/03/2017 | MARKISON BRIAN A | Director | Disposition | Employee Stock Option (Right to Buy) | 53.8k | $33.73 | $1.8M | | 10/03/2017 |
| 10/03/2017 | GOLDBERG CAROL R | Director | Disposition | Common Stock | 40.6k | $0.00 | $0 | | 10/03/2017 |
| 10/03/2017 | GOLDBERG CAROL R | Director | Disposition | Common Stock | 44.6k | $0.00 | $0 | See footnote | 10/03/2017 |
| 10/03/2017 | GOLDBERG CAROL R | Director | Disposition | Employee Stock Option (Right to Buy) | 33.5k | $29.55 | $990.4k | | 10/03/2017 |
| 10/03/2017 | GOLDBERG CAROL R | Director | Disposition | Employee Stock Option (Right to Buy) | 41.7k | $33.73 | $1.4M | | 10/03/2017 |
| 10/03/2017 | Chiniara Ellen | GC, Chief Ethics Officer&Sec | Disposition | Restricted Stock Units | 19.5k | $0.00 | $0 | | 10/03/2017 |
| 10/03/2017 | Chiniara Ellen | GC, Chief Ethics Officer&Sec | Disposition | Common Stock | 32.8k | $0.00 | $0 | | 10/03/2017 |
| 10/03/2017 | Chiniara Ellen | GC, Chief Ethics Officer&Sec | Disposition | Employee Stock Option (Right to Buy) | 8.3k | $35.58 | $296.4k | | 10/03/2017 |
| 10/03/2017 | Chiniara Ellen | GC, Chief Ethics Officer&Sec | Disposition | Employee Stock Option (Right to Buy) | 5k | $38.01 | $190k | | 10/03/2017 |
| 10/03/2017 | Chiniara Ellen | GC, Chief Ethics Officer&Sec | Disposition | Employee Stock Option (Right to Buy) | 10k | $26.06 | $260.6k | | 10/03/2017 |
| 10/03/2017 | Chiniara Ellen | GC, Chief Ethics Officer&Sec | Disposition | Employee Stock Option (Right to Buy) | 35k | $45.47 | $1.6M | | 10/03/2017 |
| 10/03/2017 | Chiniara Ellen | GC, Chief Ethics Officer&Sec | Disposition | Employee Stock Option (Right to Buy) | 5.2k | $37.42 | $196.5k | | 10/03/2017 |
| 10/03/2017 | Chiniara Ellen | GC, Chief Ethics Officer&Sec | Disposition | Employee Stock Option (Right to Buy) | 975 | $25.43 | $24.8k | | 10/03/2017 |
| 10/03/2017 | Chiniara Ellen | GC, Chief Ethics Officer&Sec | Disposition | Employee Stock Option (Right to Buy) | 11.8k | $25.68 | $302.7k | | 10/03/2017 |
| 10/03/2017 | Chiniara Ellen | GC, Chief Ethics Officer&Sec | Disposition | Employee Stock Option (Right to Buy) | 1.5k | $36.74 | $55.1k | | 10/03/2017 |
| 10/03/2017 | Roosevelt James Jr. | Director | Disposition | Common Stock | 10k | $0.00 | $0 | | 10/03/2017 |
| 10/03/2017 | Roosevelt James Jr. | Director | Disposition | Employee Stock Option (Right to Buy) | 8k | $22.74 | $181.9k | | 10/03/2017 |
| 10/03/2017 | Roosevelt James Jr. | Director | Disposition | Employee Stock Option (Right to Buy) | 49.2k | $29.55 | $1.5M | | 10/03/2017 |
| 10/03/2017 | Roosevelt James Jr. | Director | Disposition | Employee Stock Option (Right to Buy) | 41.7k | $33.73 | $1.4M | | 10/03/2017 |
| 10/03/2017 | QUELCH JOHN | Director | Disposition | Employee Stock Option (Right to Buy) | 56.3k | $33.73 | $1.9M | | 10/03/2017 |
| 10/03/2017 | QUELCH JOHN | Director | Disposition | Employee Stock Option (Right to Buy) | 41.3k | $29.55 | $1.2M | | 10/03/2017 |
| 10/03/2017 | QUELCH JOHN | Director | Disposition | Common Stock | 26.7k | $0.00 | $0 | | 10/03/2017 |
| 10/03/2017 | Hargadon Robert Bernard | SVP, Global Human Resources | Disposition | Common Stock | 26.2k | $0.00 | $0 | | 10/03/2017 |
| 10/03/2017 | Hargadon Robert Bernard | SVP, Global Human Resources | Disposition | Employee Stock Option (Right to Buy) | 20k | $29.55 | $591k | | 10/03/2017 |
| 10/03/2017 | Hargadon Robert Bernard | SVP, Global Human Resources | Disposition | Employee Stock Option (Right to Buy) | 5k | $26.06 | $130.3k | | 10/03/2017 |
| 10/03/2017 | Hargadon Robert Bernard | SVP, Global Human Resources | Disposition | Employee Stock Option (Right to Buy) | 35k | $45.47 | $1.6M | | 10/03/2017 |
| 10/03/2017 | Hargadon Robert Bernard | SVP, Global Human Resources | Disposition | Employee Stock Option (Right to Buy) | 800 | $25.43 | $20.3k | | 10/03/2017 |
| 10/03/2017 | Hargadon Robert Bernard | SVP, Global Human Resources | Disposition | Employee Stock Option (Right to Buy) | 9.6k | $25.68 | $246.5k | | 10/03/2017 |
| 10/03/2017 | Hargadon Robert Bernard | SVP, Global Human Resources | Disposition | Employee Stock Option (Right to Buy) | 1.2k | $36.74 | $45.9k | | 10/03/2017 |
| 10/03/2017 | Hargadon Robert Bernard | SVP, Global Human Resources | Disposition | Restricted Stock Units | 16.3k | $0.00 | $0 | | 10/03/2017 |
| 10/03/2017 | Pelossof Avi | GlobalPres, Infectious Disease | Disposition | Common Stock | 26k | $0.00 | $0 | | 10/03/2017 |
| 10/03/2017 | Pelossof Avi | GlobalPres, Infectious Disease | Disposition | Employee Stock Option (Right to Buy) | 10k | $19.15 | $191.5k | | 10/03/2017 |
| 10/03/2017 | Pelossof Avi | GlobalPres, Infectious Disease | Disposition | Employee Stock Option (Right to Buy) | 2.5k | $18.91 | $47.3k | | 10/03/2017 |
| 10/03/2017 | Pelossof Avi | GlobalPres, Infectious Disease | Disposition | Employee Stock Option (Right to Buy) | 14.1k | $35.58 | $501k | | 10/03/2017 |
|