| Date | Name | Symbol | Type | Security | Shares | Price | Value | Ownership | Reported |
| 03/06/2023 | Adaptive Biotechnologies Corp | ADPT | Grant | Common Stock | 14.8k | $0.00 | $0 | | 03/06/2023 |
| 03/06/2023 | Adaptive Biotechnologies Corp | ADPT | Grant | Stock Option (right to buy) | 23.3k | $8.46 | $197.4k | | 03/06/2023 |
| 02/28/2023 | EXACT SCIENCES CORP | EXAS | Sale | Common Stock | 10.4k | $61.12 | $636.6k | | 02/27/2023 |
| 02/27/2023 | EXACT SCIENCES CORP | EXAS | Exercise | Restricted Stock Units | 13.2k | $0.00 | $0 | | 02/27/2023 |
| 02/27/2023 | EXACT SCIENCES CORP | EXAS | Exercise | Restricted Stock Units | 9.3k | $0.00 | $0 | | 02/27/2023 |
| 02/22/2023 | EXACT SCIENCES CORP | EXAS | Sale | Common Stock | 4.8k | $62.72 | $298.8k | | 02/21/2023 |
| 02/21/2023 | EXACT SCIENCES CORP | EXAS | Exercise | Restricted Stock Units | 10.4k | $0.00 | $0 | | 02/21/2023 |
| 02/13/2023 | EXACT SCIENCES CORP | EXAS | Sale | Common Stock | 4.5k | $64.55 | $292.2k | | 02/10/2023 |
| 02/10/2023 | EXACT SCIENCES CORP | EXAS | Exercise | Performance Stock Units | 9.7k | $0.00 | $0 | | 02/10/2023 |
| 08/12/2022 | Epizyme, Inc. | EPZM | Disposition | Common Stock, par value $0.0001 | 53.3k | $0.00 | $0 | | 08/12/2022 |
| 08/12/2022 | Epizyme, Inc. | EPZM | Disposition | Common Stock, par value $0.0001 | 9k | $0.00 | $0 | | 08/12/2022 |
| 07/01/2022 | EXACT SCIENCES CORP | EXAS | Sale | | 7 | $40.75 | $285.2 | | 07/01/2022 |
| 06/30/2022 | Epizyme, Inc. | EPZM | Grant | Common Stock, par value $0.0001 | 10.2k | $1.47 | $15k | | 06/30/2022 |
| 05/17/2022 | Epizyme, Inc. | EPZM | Grant | Common Stock, par value $0.0001 | 9k | $0.00 | $0 | | 05/17/2022 |
| 05/17/2022 | Epizyme, Inc. | EPZM | Grant | Stock Option (Right to Buy) | 41k | $0.56 | $23k | | 05/17/2022 |
| 05/02/2022 | EXACT SCIENCES CORP | EXAS | Grant | Common Stock | 328 | $47.41 | $15.6k | | 07/01/2022 |
| 03/31/2022 | Epizyme, Inc. | EPZM | Grant | Common Stock, par value $0.0001 | 13k | $1.15 | $15k | | 03/31/2022 |
| 03/17/2022 | EXACT SCIENCES CORP | EXAS | Exercise | Stock Option (right to buy) | 4.6k | $21.68 | $100k | | 03/17/2022 |
| 03/17/2022 | EXACT SCIENCES CORP | EXAS | Exercise | Stock Option (right to buy) | 2.3k | $44.37 | $100k | | 03/17/2022 |
| 03/17/2022 | EXACT SCIENCES CORP | EXAS | Exercise | Stock Option (right to buy) | 229.8k | $5.70 | $1.3M | | 03/17/2022 |
| 03/01/2022 | EXACT SCIENCES CORP | EXAS | Sale | Common Stock | 14.3k | $76.69 | $1.1M | | 02/28/2022 |
| 02/28/2022 | EXACT SCIENCES CORP | EXAS | Exercise | Restricted Stock Units | 20.6k | $0.00 | $0 | | 02/28/2022 |
| 02/28/2022 | EXACT SCIENCES CORP | EXAS | Exercise | Restricted Stock Units | 9.3k | $0.00 | $0 | | 02/28/2022 |
| 02/25/2022 | EXACT SCIENCES CORP | EXAS | Grant | Restricted Stock Units | 52.7k | $0.00 | $0 | | 02/25/2022 |
| 02/24/2022 | EXACT SCIENCES CORP | EXAS | Sale | Common Stock | 27.1k | $70.10 | $1.9M | | 02/23/2022 |
| 02/23/2022 | EXACT SCIENCES CORP | EXAS | Exercise | Performance Stock Units | 58.6k | $0.00 | $0 | | 02/23/2022 |
| 02/23/2022 | EXACT SCIENCES CORP | EXAS | Sale | Common Stock | 5.2k | $69.05 | $358.2k | | 02/22/2022 |
| 02/22/2022 | EXACT SCIENCES CORP | EXAS | Exercise | Restricted Stock Units | 10.4k | $0.00 | $0 | | 02/22/2022 |
| 02/15/2022 | EXACT SCIENCES CORP | EXAS | Sale | Common Stock | 14.4k | $79.55 | $1.1M | | 02/14/2022 |
| 02/14/2022 | EXACT SCIENCES CORP | EXAS | Exercise | Stock Option (right to buy) | 94.4k | $9.07 | $856.4k | | 02/14/2022 |
| 02/14/2022 | EXACT SCIENCES CORP | EXAS | Exercise | Stock Option (right to buy) | 96.8k | $10.82 | $1M | | 02/14/2022 |
| 02/14/2022 | EXACT SCIENCES CORP | EXAS | Exercise | Restricted Stock Units | 31.1k | $0.00 | $0 | | 02/14/2022 |
| 02/14/2022 | EXACT SCIENCES CORP | EXAS | Exercise | Common Stock | 31.1k | $78.33 | $2.4M | | 02/14/2022 |
| 01/26/2022 | Adaptive Biotechnologies Corp | ADPT | Grant | Common Stock | 6.7k | $0.00 | $0 | | 01/26/2022 |
| 01/26/2022 | Adaptive Biotechnologies Corp | ADPT | Grant | Stock Option (Right to Buy) | 16.7k | $14.95 | $250k | | 01/26/2022 |
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