| Date | Name | Symbol | Type | Security | Shares | Price | Value | Ownership | Reported |
| 06/01/2023 | Denali Therapeutics Inc. | DNLI | Grant | Stock Option (right to buy) | 12.6k | $30.92 | $391.1k | | 06/01/2023 |
| 06/01/2023 | Denali Therapeutics Inc. | DNLI | Grant | Common Stock | 4.2k | $0.00 | $0 | | 06/01/2023 |
| 01/03/2023 | REGENERON PHARMACEUTICALS, INC. | REGN | Grant | Common Stock | 165 | $0.00 | $0 | | 01/03/2023 |
| 01/03/2023 | REGENERON PHARMACEUTICALS, INC. | REGN | Grant | Non-Qualified Stock Option (right to buy) | 1.9k | $725.89 | $1.4M | | 01/03/2023 |
| 01/03/2023 | REGENERON PHARMACEUTICALS, INC. | REGN | Grant | Common Stock | 165 | $0.00 | $0 | | 01/03/2023 |
| 01/03/2023 | REGENERON PHARMACEUTICALS, INC. | REGN | Grant | Non-Qualified Stock Option (right to buy) | 1.9k | $725.89 | $1.4M | | 01/03/2023 |
| 11/23/2022 | Denali Therapeutics Inc. | DNLI | Sale | Common Stock | 20k | $30.48 | $609.6k | | 11/23/2022 |
| 11/02/2022 | Denali Therapeutics Inc. | DNLI | Sale | Common Stock | 11.3k | $30.33 | $341.3k | | 11/01/2022 |
| 11/01/2022 | Denali Therapeutics Inc. | DNLI | Sale | Common Stock | 8.7k | $30.20 | $264.2k | | 11/01/2022 |
| 10/03/2022 | REGENERON PHARMACEUTICALS, INC. | REGN | Sale | Common Stock | 3.6k | $718.00 | $2.6M | | 09/29/2022 |
| 10/03/2022 | REGENERON PHARMACEUTICALS, INC. | REGN | Exercise | Non-Qualified Stock Option (right to buy) | 3.6k | $413.33 | $1.5M | | 09/29/2022 |
| 09/30/2022 | REGENERON PHARMACEUTICALS, INC. | REGN | Exercise | Non-Qualified Stock Option (right to buy) | 3.4k | $413.33 | $1.4M | | 09/29/2022 |
| 09/30/2022 | REGENERON PHARMACEUTICALS, INC. | REGN | Sale | Common Stock | 3.4k | $698.00 | $2.4M | | 09/29/2022 |
| 09/29/2022 | REGENERON PHARMACEUTICALS, INC. | REGN | Sale | Common Stock | 20 | $704.83 | $14.1k | | 09/29/2022 |
| 09/29/2022 | REGENERON PHARMACEUTICALS, INC. | REGN | Sale | Common Stock | 16 | $702.36 | $11.2k | | 09/29/2022 |
| 09/29/2022 | REGENERON PHARMACEUTICALS, INC. | REGN | Sale | Common Stock | 80 | $699.82 | $56k | | 09/29/2022 |
| 09/29/2022 | REGENERON PHARMACEUTICALS, INC. | REGN | Sale | Common Stock | 208 | $698.44 | $145.3k | | 09/29/2022 |
| 09/29/2022 | REGENERON PHARMACEUTICALS, INC. | REGN | Sale | Common Stock | 160 | $697.29 | $111.6k | | 09/29/2022 |
| 09/29/2022 | REGENERON PHARMACEUTICALS, INC. | REGN | Sale | Common Stock | 85 | $696.13 | $59.2k | | 09/29/2022 |
| 09/29/2022 | REGENERON PHARMACEUTICALS, INC. | REGN | Sale | Common Stock | 554 | $691.59 | $383.1k | | 09/29/2022 |
| 09/29/2022 | REGENERON PHARMACEUTICALS, INC. | REGN | Exercise | Non-Qualified Stock Option (right to buy) | 3.8k | $413.33 | $1.6M | | 09/29/2022 |
| 09/29/2022 | REGENERON PHARMACEUTICALS, INC. | REGN | Sale | Common Stock | 692 | $690.65 | $477.9k | | 09/29/2022 |
| 09/29/2022 | REGENERON PHARMACEUTICALS, INC. | REGN | Sale | Common Stock | 1k | $689.56 | $695.8k | | 09/29/2022 |
| 09/29/2022 | REGENERON PHARMACEUTICALS, INC. | REGN | Sale | Common Stock | 637 | $688.71 | $438.7k | | 09/29/2022 |
| 09/29/2022 | REGENERON PHARMACEUTICALS, INC. | REGN | Sale | Common Stock | 321 | $687.90 | $220.8k | | 09/29/2022 |
| 09/29/2022 | REGENERON PHARMACEUTICALS, INC. | REGN | Sale | Common Stock | 16 | $686.89 | $11k | | 09/29/2022 |
| 09/28/2022 | Denali Therapeutics Inc. | DNLI | Sale | Common Stock | 15.6k | $30.74 | $478.8k | | 09/28/2022 |
| 09/28/2022 | Denali Therapeutics Inc. | DNLI | Sale | Common Stock | 4.4k | $31.08 | $137.5k | | 09/28/2022 |
| 08/23/2022 | Denali Therapeutics Inc. | DNLI | Sale | Common Stock | 19.9k | $31.61 | $629k | | 08/23/2022 |
| 08/23/2022 | Denali Therapeutics Inc. | DNLI | Sale | Common Stock | 100 | $32.43 | $3.2k | | 08/23/2022 |
| 07/25/2022 | Denali Therapeutics Inc. | DNLI | Sale | Common Stock | 19.8k | $35.60 | $704.9k | | 07/25/2022 |
| 07/25/2022 | Denali Therapeutics Inc. | DNLI | Sale | Common Stock | 200 | $36.15 | $7.2k | | 07/25/2022 |
| 06/24/2022 | Denali Therapeutics Inc. | DNLI | Disposition | Common Stock | 6.8k | $31.08 | $210.3k | | 06/23/2022 |
| 06/24/2022 | Denali Therapeutics Inc. | DNLI | Disposition | Common Stock | 40k | $30.53 | $1.2M | | 06/23/2022 |
| 06/23/2022 | Denali Therapeutics Inc. | DNLI | Disposition | Common Stock | 13.2k | $31.10 | $412.1k | | 06/23/2022 |
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