| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 05/02/2008 | HEMBERGER JUDITH A | Director | Disposition | Non-Qualified Stock Option (right to buy) | 11.1k | $3.42 | $38k | | 05/02/2008 |
| 05/02/2008 | Perry Marlene F | SVP, HR & Facilities | Disposition | Common Stock | 106k | $0.00 | $0 | | 05/02/2008 |
| 05/02/2008 | CROWELL NANCY M | Director | Disposition | Non-Qualified Stock Option (right to buy) | 4.4k | $1.13 | $5k | | 05/02/2008 |
| 05/02/2008 | CROWELL NANCY M | Director | Disposition | Non-Qualified Stock Option (right to buy) | 11.1k | $3.42 | $38k | | 05/02/2008 |
| 05/02/2008 | EVNIN ANTHONY B | Director | Disposition | Common Stock | 5.7k | $0.00 | $0 | | 05/02/2008 |
| 05/02/2008 | EVNIN ANTHONY B | Director | Disposition | Non-Qualified Stock Option (right to buy) | 11.1k | $18.19 | $202.1k | | 05/02/2008 |
| 05/02/2008 | EVNIN ANTHONY B | Director | Disposition | Non-Qualified Stock Option (right to buy) | 11.1k | $3.42 | $38k | | 05/02/2008 |
| 05/02/2008 | Farrow Jeffrey S | V.P., Finance and CAO | Disposition | Incentive Stock Option (right to buy) | 25.5k | $2.62 | $66.8k | | 05/02/2008 |
| 05/02/2008 | Farrow Jeffrey S | V.P., Finance and CAO | Disposition | Non-Qualified Stock Option (right to buy) | 756 | $2.62 | $2k | | 05/02/2008 |
| 05/02/2008 | CROWELL NANCY M | Director | Disposition | Non-Qualified Stock Option (right to buy) | 22.2k | $4.50 | $100k | | 05/02/2008 |
| 05/02/2008 | EVNIN ANTHONY B | Director | Disposition | Common Stock | 1.3M | $0.00 | $0 | By Funds | 05/02/2008 |
| 05/02/2008 | EVNIN ANTHONY B | Director | Disposition | Non-Qualified Stock Option (right to buy) | 22.2k | $4.50 | $100k | | 05/02/2008 |
| 05/02/2008 | EVNIN ANTHONY B | Director | Disposition | Non-Qualified Stock Option (right to buy) | 11.1k | $11.70 | $130k | | 05/02/2008 |
| 05/02/2008 | WALKER JOHN PETER | Director | Disposition | Common Stock | 160.8k | $0.00 | $0 | | 05/02/2008 |
| 05/02/2008 | WALKER JOHN PETER | Director | Disposition | Non-Qualified Stock Option (right to buy) | 4.4k | $1.13 | $5k | | 05/02/2008 |
| 05/02/2008 | WALKER JOHN PETER | Director | Disposition | Non-Qualified Stock Option (right to buy) | 22.2k | $3.42 | $76k | | 05/02/2008 |
| 05/02/2008 | WALKER JOHN PETER | Director | Disposition | Non-Qualified Stock Option (right to buy) | 22.2k | $4.50 | $100k | | 05/02/2008 |
| 05/02/2008 | WALKER JOHN PETER | Director | Disposition | Non-Qualified Stock Option (right to buy) | 11.1k | $8.16 | $90.7k | | 05/02/2008 |
| 05/02/2008 | GOODMAN COREY S | Director | Disposition | Common Stock | 285.4k | $0.00 | $0 | By Trust | 05/02/2008 |
| 05/02/2008 | GOODMAN COREY S | Director | Disposition | Incentive Stock Option (right to buy) | 5.6k | $1.13 | $6.3k | | 05/02/2008 |
| 05/02/2008 | GOODMAN COREY S | Director | Disposition | Non_Qualified Stock Option (right to buy) | 116.7k | $1.35 | $157.5k | | 05/02/2008 |
| 05/02/2008 | GOODMAN COREY S | Director | Disposition | Non_Qualified Stock Option (right to buy) | 24.4k | $1.13 | $27.5k | | 05/02/2008 |
| 05/02/2008 | GOODMAN COREY S | Director | Disposition | Non_Qualified Stock Option (right to buy) | 133.3k | $4.50 | $600k | | 05/02/2008 |
| 05/02/2008 | Farrow Jeffrey S | V.P., Finance and CAO | Disposition | Common Stock | 62.3k | $0.00 | $0 | | 05/02/2008 |
| 05/02/2008 | Farrow Jeffrey S | V.P., Finance and CAO | Disposition | Incentive Stock Option (right to buy) | 15.5k | $5.40 | $83.8k | | 05/02/2008 |
| 05/02/2008 | Farrow Jeffrey S | V.P., Finance and CAO | Disposition | Non-Qualified Stock Option (right to buy) | 1.7k | $5.40 | $9.2k | | 05/02/2008 |
| 05/02/2008 | KELLY MICHAEL GERALD | SVP, Research & Development | Disposition | Non-Qualified Stock Option (right to buy) | 38.9k | $1.35 | $52.5k | | 05/02/2008 |
| 05/02/2008 | KELLY MICHAEL GERALD | SVP, Research & Development | Disposition | Non-Qualified Stock Option (right to buy) | 47.8k | $4.50 | $215k | | 05/02/2008 |
| 05/02/2008 | KELLY MICHAEL GERALD | SVP, Research & Development | Disposition | Incentive Stock Option (right to buy) | 100k | $2.62 | $262k | | 05/02/2008 |
| 05/02/2008 | FRIEDMAN JOHN H | Director | Disposition | Non-Qualified Stock Options (right to buy) | 11.1k | $3.42 | $38k | | 05/02/2008 |
| 05/02/2008 | FRIEDMAN JOHN H | Director | Disposition | Non-Qualified Stock Options (right to buy) | 22.2k | $4.50 | $100k | | 05/02/2008 |
| 05/02/2008 | KELLY MICHAEL GERALD | SVP, Research & Development | Disposition | Common Stock | 197.1k | $0.00 | $0 | | 05/02/2008 |
| 05/02/2008 | KELLY MICHAEL GERALD | SVP, Research & Development | Disposition | Incentive Stock Option (right to buy) | 27.8k | $1.35 | $37.5k | | 05/02/2008 |
| 05/02/2008 | CARTER BRUCE L A | Director | Disposition | Non-Qualified Stock Option (right to buy) | 11.1k | $3.42 | $38k | | 05/02/2008 |
| 05/02/2008 | CARTER BRUCE L A | Director | Disposition | Non-Qualified Stock Option (right to buy) | 22.2k | $6.80 | $151.1k | | 05/02/2008 |
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