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TWO SIGMA INVESTMENTS, LP
> AVRO
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | AVROBIO, Inc. | AVRO | 285,861 | -47,137 | 271,597,000 | -61,401,000 | $950.10 |
| 03/31/2023 | AVROBIO, Inc. | AVRO | 332,998 | 15,147 | 332,998,000 | 106,402,000 | $1,000.00 |
| 12/31/2022 | AVROBIO, Inc. | AVRO | 317,851 | -155,793 | 226,596,000 | 226,160,000 | $712.90 |
| 06/30/2022 | AVROBIO, Inc. | AVRO | 473,644 | -198,789 | 436,000 | -452,000 | $0.92 |
| 03/31/2022 | AVROBIO, Inc. | AVRO | 672,433 | 200,499 | 888,000 | -929,000 | $1.32 |
| 12/31/2021 | AVROBIO, Inc. | AVRO | 471,934 | 144,686 | 1,817,000 | -9,000 | $3.85 |
| 09/30/2021 | AVROBIO, Inc. | AVRO | 327,248 | 205,800 | 1,826,000 | 746,000 | $5.58 |
| 06/30/2021 | AVROBIO, Inc. | AVRO | 121,448 | 1,577 | 1,080,000 | -441,000 | $8.89 |
| 03/31/2021 | AVROBIO, Inc. | AVRO | 119,871 | 26,491 | 1,521,000 | 219,000 | $12.69 |
| 12/31/2020 | AVROBIO, Inc. | AVRO | 93,380 | 80,438 | 1,302,000 | 1,133,000 | $13.94 |
| 09/30/2020 | AVROBIO, Inc. | AVRO | 12,942 | -52,921 | 169,000 | -980,000 | $13.06 |
| 06/30/2020 | AVROBIO, Inc. | AVRO | 65,863 | 65,863 | 1,149,000 | 1,149,000 | $17.45 |
| 03/31/2020 | AVROBIO, Inc. | AVRO | 0 | -37,501 | 0 | -755,000 | |
| 12/31/2019 | AVROBIO, Inc. | AVRO | 37,501 | 37,501 | 755,000 | 755,000 | $20.13 |
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