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Cubist Systematic Strategies, LLC
> LXRX
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | LEXICON PHARMACEUTICALS, INC. | LXRX | 179,327 | 173,405 | 410,659,000 | 396,268,000 | $2,290.00 |
| 03/31/2023 | LEXICON PHARMACEUTICALS, INC. | LXRX | 5,922 | -12,323 | 14,391,000 | -20,457,000 | $2,430.09 |
| 12/31/2022 | LEXICON PHARMACEUTICALS, INC. | LXRX | 18,245 | -4,600 | 34,848,000 | 34,793,000 | $1,910.00 |
| 09/30/2022 | LEXICON PHARMACEUTICALS, INC. | LXRX | 22,845 | 22,845 | 55,000 | 55,000 | $2.41 |
| 06/30/2022 | LEXICON PHARMACEUTICALS, INC. | LXRX | 0 | -10,816 | 0 | -23,000 | |
| 03/31/2022 | LEXICON PHARMACEUTICALS, INC. | LXRX | 10,816 | -55,992 | 23,000 | -240,000 | $2.13 |
| 12/31/2021 | LEXICON PHARMACEUTICALS, INC. | LXRX | 66,808 | 66,808 | 263,000 | 263,000 | $3.94 |
| 06/30/2021 | LEXICON PHARMACEUTICALS, INC. | LXRX | 0 | -45,047 | 0 | -154,000 | |
| 12/31/2020 | LEXICON PHARMACEUTICALS, INC. | LXRX | 45,047 | 45,047 | 154,000 | 154,000 | $3.42 |
| 12/31/2019 | LEXICON PHARMACEUTICALS, INC. | LXRX | 0 | -42,879 | 0 | -129,000 | |
| 09/30/2019 | LEXICON PHARMACEUTICALS, INC. | LXRX | 42,879 | 42,879 | 129,000 | 129,000 | $3.01 |
| 06/30/2019 | LEXICON PHARMACEUTICALS, INC. | LXRX | 0 | -20,828 | 0 | -116,000 | |
| 03/31/2019 | LEXICON PHARMACEUTICALS, INC. | LXRX | 20,828 | 10,156 | 116,000 | 45,000 | $5.57 |
| 12/31/2018 | LEXICON PHARMACEUTICALS, INC. | LXRX | 10,672 | -6,700 | 71,000 | -114,000 | $6.65 |
| 09/30/2018 | LEXICON PHARMACEUTICALS, INC. | LXRX | 17,372 | -11,033 | 185,000 | -156,000 | $10.65 |
| 06/30/2018 | LEXICON PHARMACEUTICALS, INC. | LXRX | 28,405 | 2,373 | 341,000 | 118,000 | $12.00 |
| 03/31/2018 | LEXICON PHARMACEUTICALS, INC. | LXRX | 26,032 | 4,569 | 223,000 | 11,000 | $8.57 |
| 12/31/2017 | LEXICON PHARMACEUTICALS, INC. | LXRX | 21,463 | 9,321 | 212,000 | 63,000 | $9.88 |
| 09/30/2017 | LEXICON PHARMACEUTICALS, INC. | LXRX | 12,142 | 12,142 | 149,000 | 149,000 | $12.27 |
| 06/30/2017 | LEXICON PHARMACEUTICALS, INC. | LXRX | 0 | -14,055 | 0 | -202,000 | |
| 03/31/2017 | LEXICON PHARMACEUTICALS, INC. | LXRX | 14,055 | 14,055 | 202,000 | 202,000 | $14.37 |
| 12/31/2016 | LEXICON PHARMACEUTICALS, INC. | LXRX | 0 | -17,292 | 0 | -312,000 | |
| 09/30/2016 | LEXICON PHARMACEUTICALS, INC. | LXRX | 17,292 | 17,292 | 312,000 | 312,000 | $18.04 |
| 06/30/2016 | LEXICON PHARMACEUTICALS, INC. | LXRX | 0 | -13,814 | 0 | -111,000 | |
| 09/30/2015 | LEXICON PHARMACEUTICALS, INC. | LXRX | 0 | -13,814 | 0 | -111,000 | |
| 06/30/2015 | LEXICON PHARMACEUTICALS, INC. | LXRX | 13,814 | 13,814 | 111,000 | 111,000 | $8.04 |
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