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MILLENNIUM MANAGEMENT LLC
> AVRO
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | AVROBIO, Inc. | AVRO | 181,590 | -507,095 | 172,529,000 | 172,038,000 | $950.10 |
| 12/31/2022 | AVROBIO, Inc. | AVRO | 688,685 | -20,852 | 491,000 | 35,000 | $0.71 |
| 09/30/2022 | AVROBIO, Inc. | AVRO | 709,537 | -84,985 | 456,000 | -275,000 | $0.64 |
| 06/30/2022 | AVROBIO, Inc. | AVRO | 794,522 | 270,083 | 731,000 | 39,000 | $0.92 |
| 03/31/2022 | AVROBIO, Inc. | AVRO | 524,439 | -111,938 | 692,000 | -1,758,000 | $1.32 |
| 12/31/2021 | AVROBIO, Inc. | AVRO | 636,377 | -203,572 | 2,450,000 | -2,237,000 | $3.85 |
| 09/30/2021 | AVROBIO, Inc. | AVRO | 839,949 | 271,626 | 4,687,000 | -365,000 | $5.58 |
| 06/30/2021 | AVROBIO, Inc. | AVRO | 568,323 | -117,768 | 5,052,000 | -3,654,000 | $8.89 |
| 03/31/2021 | AVROBIO, Inc. | AVRO | 686,091 | -207,773 | 8,706,000 | -3,754,000 | $12.69 |
| 12/31/2020 | AVROBIO, Inc. | AVRO | 893,864 | 354,909 | 12,460,000 | 3,055,000 | $13.94 |
| 06/30/2020 | AVROBIO, Inc. | AVRO | 538,955 | 73,361 | 9,405,000 | 2,160,000 | $17.45 |
| 03/31/2020 | AVROBIO, Inc. | AVRO | 465,594 | 304,213 | 7,245,000 | 3,996,000 | $15.56 |
| 12/31/2019 | AVROBIO, Inc. | AVRO | 161,381 | 161,381 | 3,249,000 | 3,249,000 | $20.13 |
| 09/30/2019 | AVROBIO, Inc. | AVRO | 0 | -30,010 | 0 | -488,000 | |
| 06/30/2019 | AVROBIO, Inc. | AVRO | 30,010 | 30,010 | 488,000 | 488,000 | $16.26 |
| 12/31/2018 | AVROBIO, Inc. | AVRO | 0 | -350,877 | 0 | -18,200,000 | |
| 09/30/2018 | AVROBIO, Inc. | AVRO | 350,877 | 139,982 | 18,200,000 | 12,177,000 | $51.87 |
| 06/30/2018 | AVROBIO, Inc. | AVRO | 210,895 | 210,895 | 6,023,000 | 6,023,000 | $28.56 |
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