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BIOSPHERE MEDICAL INC (BSMD)

Portfolio as of:
NameSharesChangeValue% Port% OSHistDate
WADE G W & INC 316,000122,00058,946,0000.67  Hist 06/30/2010
DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C) 1,766,52607,631,0000.49  Hist 06/30/2010
FEINBERG STEPHEN 1,559,26806,736,0000.408.47 Hist 06/30/2010
Centaurus Capital LP 1,202,410243,7545,194,0000.896.53 Hist 06/30/2010
CLOUGH CAPITAL PARTNERS L P 1,226,312-79,9843,167,0000.15  Hist 03/31/2010
Flynn James E 1,098,061-24,8523,008,687   Hist 12/31/2009
RMB Capital Management, LLC 983,591-74,5002,607,0000.35  Hist 03/31/2010
COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS 562,000562,0002,428,0000.00  Hist 06/30/2010
GLAZER CAPITAL, LLC 547,010547,0102,363,0830.622.97 Hist 06/30/2010
AQR CAPITAL MANAGEMENT LLC 502,485502,4852,171,0000.022.73 Hist 06/30/2010
WATER ISLAND CAPITAL LLC 396,344396,3441,712,0000.15  Hist 06/30/2010
DIMENSIONAL FUND ADVISORS LP 368,595-2,0281,592,0000.002.00 Hist 06/30/2010
LOEB ARBITRAGE MANAGEMENT LP 364,116364,1161,573,0000.771.98 Hist 06/30/2010
VANGUARD GROUP INC 331,41601,432,0000.001.80 Hist 06/30/2010
BlackRock Institutional Trust Company, N.A. 330,59544,7661,428,0000.001.79 Hist 06/30/2010
Portolan Capital Management, LLC 314,694-926,6201,359,0000.311.71 Hist 06/30/2010
RENAISSANCE TECHNOLOGIES LLC 217,40086,600939,0000.00  Hist 06/30/2010
GARDNER LEWIS ASSET MANAGEMENT L P 211,575211,575914,0000.041.15 Hist 06/30/2010
CREDIT AGRICOLE S A 119,833119,833518,0000.000.65 Hist 06/30/2010
NSB Advisors LLC 100,0000432,0000.070.54 Hist 06/30/2010
OPPENHEIMER & CO INC 83,0000227,0000.01  Hist 12/31/2009
OXFORD ASSET MANAGEMENT LLP 43,80643,806189,0000.010.24 Hist 06/30/2010
AQR Arbitrage LLC 42,04042,040182,0000.01  Hist 06/30/2010
Hardman Johnston Global Advisors LLC 40,0000173,0000.01  Hist 06/30/2010
BlackRock Fund Advisors 36,6743,024158,0000.000.20 Hist 06/30/2010
TFS CAPITAL LLC 35,37535,375153,0000.02  Hist 06/30/2010
Ancora Advisors, LLC 35,00035,000151,0000.090.19 Hist 06/30/2010
BLAIR WILLIAM & CO/IL 27,600-27,600119,0000.00  Hist 06/30/2010
DAFNA Capital Management LLC 40,38930,928107,0000.21  Hist 03/31/2010
MORGAN STANLEY 21,94621,94695,0000.000.12 Hist 06/30/2010
UBS AG 19,67218,43284,9800.000.11 Hist 06/30/2010
GEODE CAPITAL MANAGEMENT, LLC 15,62815,62868,0000.00  Hist 06/30/2010
Bank of New York Mellon Corp 12,826055,0000.000.07 Hist 06/30/2010
ALGERT GLOBAL LLC 4,815-4,34021,0000.010.03 Hist 06/30/2010
WELLS FARGO & COMPANY/MN 2,900-40013,0000.00  Hist 06/30/2010
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