| Date | Name | Symbol | Type | Security | Shares | Price | Value | Ownership | Reported |
| 08/24/2023 | Xenon Pharmaceuticals Inc. | XENE | Sale | Common Shares | 25k | $38.70 | $967.5k | | 08/24/2023 |
| 06/02/2023 | Xenon Pharmaceuticals Inc. | XENE | Grant | Stock Option (Right to Buy) | 18.5k | $38.96 | $719.8k | | 06/02/2023 |
| 05/09/2023 | ACELYRIN, Inc. | | Purchase | Common Stock | 15k | $18.00 | $270k | | 05/09/2023 |
| 05/09/2023 | ACELYRIN, Inc. | | Other (disposition) | Director Stock Option (right to buy) | 155.4k | $5.88 | $913.5k | | 05/09/2023 |
| 05/09/2023 | ACELYRIN, Inc. | | Other (acquisition) | Director Stock Option (right to buy) | 155.4k | $5.88 | $913.5k | | 05/09/2023 |
| 05/09/2023 | ACELYRIN, Inc. | | Other (disposition) | Director Stock Option (right to buy) | 23.2k | $18.00 | $418.4k | | 05/09/2023 |
| 05/09/2023 | ACELYRIN, Inc. | | Other (acquisition) | Director Stock Option (right to buy) | 23.2k | $18.00 | $418.4k | | 05/09/2023 |
| 05/04/2023 | ACELYRIN, Inc. | | Grant | Director Stock Option (right to buy) | 23.2k | $18.00 | $418.4k | | 05/04/2023 |
| 10/05/2022 | Global Blood Therapeutics, Inc. | GBT | Disposition | Common Stock | 5.4k | $0.00 | $0 | | 10/05/2022 |
| 10/05/2022 | Global Blood Therapeutics, Inc. | GBT | Disposition | Restricted Stock Units | 3.6k | $0.00 | $0 | | 10/05/2022 |
| 10/05/2022 | Global Blood Therapeutics, Inc. | GBT | Disposition | Stock Option (Right to Buy) | 30k | $38.68 | $1.2M | | 10/05/2022 |
| 10/05/2022 | Global Blood Therapeutics, Inc. | GBT | Disposition | Stock Option (Right to Buy) | 7.5k | $56.30 | $422.2k | | 10/05/2022 |
| 10/05/2022 | Global Blood Therapeutics, Inc. | GBT | Disposition | Stock Option (Right to Buy) | 5.2k | $64.75 | $339.7k | | 10/05/2022 |
| 10/05/2022 | Global Blood Therapeutics, Inc. | GBT | Disposition | Stock Option (Right to Buy) | 5.6k | $37.09 | $207.7k | | 10/05/2022 |
| 10/05/2022 | Global Blood Therapeutics, Inc. | GBT | Disposition | Stock Option (Right to Buy) | 5.6k | $22.30 | $124.9k | | 10/05/2022 |
| 06/28/2022 | Xenon Pharmaceuticals Inc. | XENE | Grant | Stock Option (Right to Buy) | 18k | $30.11 | $542k | | 06/28/2022 |
| 06/21/2022 | Global Blood Therapeutics, Inc. | GBT | Sale | Common Stock | 1.9k | $27.24 | $52k | | 06/21/2022 |
| 06/14/2022 | Global Blood Therapeutics, Inc. | GBT | Exercise | Restricted Stock Units | 3.6k | $0.00 | $0 | | 06/14/2022 |
| 06/14/2022 | Global Blood Therapeutics, Inc. | GBT | Grant | Stock Option (Right to Buy) | 5.6k | $22.30 | $124.9k | | 06/14/2022 |
| 06/14/2022 | Global Blood Therapeutics, Inc. | GBT | Grant | Restricted Stock Units | 3.6k | $0.00 | $0 | | 06/14/2022 |
| 06/10/2022 | Adverum Biotechnologies, Inc. | ADVM | Grant | Stock Option (Right to Buy) | 40k | $0.99 | $39.6k | | 06/10/2022 |
| 06/09/2022 | PTC THERAPEUTICS, INC. | PTCT | Sale | Common Stock | 738 | $27.20 | $20.1k | | 06/09/2022 |
| 05/16/2022 | Adverum Biotechnologies, Inc. | ADVM | Purchase | Common Stock | 30k | $0.85 | $25.6k | | 05/16/2022 |
| 01/07/2022 | PTC THERAPEUTICS, INC. | PTCT | Sale | Common Stock | 510 | $38.53 | $19.6k | | 01/07/2022 |
| 01/07/2022 | PTC THERAPEUTICS, INC. | PTCT | Grant | Common Stock | 3.2k | $0.00 | $0 | | 01/07/2022 |
| 01/07/2022 | PTC THERAPEUTICS, INC. | PTCT | Grant | Stock Option (Right To Buy) | 12k | $38.10 | $457.2k | | 01/07/2022 |
| 06/18/2021 | Global Blood Therapeutics, Inc. | GBT | Sale | Common Stock | 1.6k | $36.54 | $58.8k | | 06/17/2021 |
| 06/17/2021 | Global Blood Therapeutics, Inc. | GBT | Exercise | Restricted Stock Units | 3k | $0.00 | $0 | | 06/17/2021 |
| 06/17/2021 | Global Blood Therapeutics, Inc. | GBT | Grant | Stock Option (Right to Buy) | 5.6k | $37.09 | $207.7k | | 06/17/2021 |
| 06/17/2021 | Global Blood Therapeutics, Inc. | GBT | Grant | Restricted Stock Units | 3.6k | $0.00 | $0 | | 06/17/2021 |
| 06/09/2021 | PTC THERAPEUTICS, INC. | PTCT | Sale | Common Stock | 365 | $41.89 | $15.3k | | 06/09/2021 |
| 06/03/2021 | Xenon Pharmaceuticals Inc. | XENE | Grant | Stock Option (Right to Buy) | 10k | $18.56 | $185.6k | | 06/03/2021 |
| 05/12/2021 | Adverum Biotechnologies, Inc. | ADVM | Grant | Stock Option (Right to Buy) | 40k | $3.70 | $148k | | 05/12/2021 |
| 03/31/2021 | Adverum Biotechnologies, Inc. | ADVM | Purchase | Common Stock | 20k | $10.02 | $200.3k | | 03/31/2021 |
| 02/01/2021 | PTC THERAPEUTICS, INC. | PTCT | Sale | Common Stock | 506 | $56.96 | $28.8k | | 02/01/2021 |
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