| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 06/07/2023 | Rubinstein Linda M | CFO | Purchase | Common Stock | 100k | $1.45 | $145.5k | | 06/07/2023 |
| 03/15/2023 | Riley Brigit | Chief Scientific Officer | Sale | Common Stock | 7.3k | $0.78 | $5.7k | | 03/15/2023 |
| 03/15/2023 | Fischer Laurent | CEO, President and Director | Sale | Common Stock | 41.2k | $0.78 | $32.2k | | 03/15/2023 |
| 03/15/2023 | Soparkar Peter | COO | Sale | Common Stock | 13.4k | $0.78 | $10.4k | | 03/15/2023 |
| 09/19/2022 | Fischer Laurent | CEO, President and Director | Sale | Common Stock | 41.1k | $1.07 | $43.9k | | 09/19/2022 |
| 09/19/2022 | Riley Brigit | Chief Scientific Officer | Sale | Common Stock | 7.3k | $1.07 | $7.8k | | 09/19/2022 |
| 09/19/2022 | Soparkar Peter | COO | Sale | Common Stock | 13.3k | $1.07 | $14.2k | | 09/19/2022 |
| 09/19/2022 | Seyedkazemi Setareh | Chief Development Officer | Sale | Common Stock | 6.1k | $1.07 | $6.5k | | 09/19/2022 |
| 09/19/2022 | Beckman Richard | Chief Medical Officer | Sale | Common Stock | 4.3k | $1.07 | $4.6k | | 09/19/2022 |
| 09/14/2022 | Beckman Richard | Chief Medical Officer | Grant | Common Stock | 33.3k | $0.00 | $0 | | 09/14/2022 |
| 09/14/2022 | Rakow John | SVP, Genl Counsel, Acting CFO | Grant | Stock Option (Right to Buy) | 42.8k | $1.09 | $46.7k | | 09/14/2022 |
| 09/14/2022 | Rakow John | SVP, Genl Counsel, Acting CFO | Grant | Performance Based Stock Option (Right to Buy) | 75.3k | $1.09 | $82k | | 09/14/2022 |
| 09/14/2022 | Soparkar Peter | COO | Grant | Stock Option (Right to Buy) | 163.8k | $1.09 | $178.6k | | 09/14/2022 |
| 09/14/2022 | Riley Brigit | Chief Scientific Officer | Grant | Stock Option (Right to Buy) | 95.9k | $1.09 | $104.6k | | 09/14/2022 |
| 09/14/2022 | Riley Brigit | Chief Scientific Officer | Grant | Performance Based Stock Option (Right to Buy) | 68.5k | $1.09 | $74.6k | | 09/14/2022 |
| 09/14/2022 | Soparkar Peter | COO | Grant | Performance Based Stock Option (Right to Buy) | 230.9k | $1.09 | $251.7k | | 09/14/2022 |
| 09/14/2022 | Fischer Laurent | CEO, President and Director | Grant | Stock Option (Right to Buy) | 675k | $1.09 | $735.8k | | 09/14/2022 |
| 09/14/2022 | Fischer Laurent | CEO, President and Director | Grant | Performance Based Stock Option (Right to Buy) | 585k | $1.09 | $637.6k | | 09/14/2022 |
| 09/14/2022 | Seyedkazemi Setareh | Chief Development Officer | Grant | Common Stock | 33.3k | $0.00 | $0 | | 09/14/2022 |
| 09/14/2022 | Beckman Richard | Chief Medical Officer | Grant | Common Stock | 25k | $0.00 | $0 | | 09/14/2022 |
| 06/10/2022 | Tuckson Reed Vaughn | Director | Grant | Stock Option (Right to Buy) | 40k | $0.99 | $39.6k | | 06/10/2022 |
| 06/10/2022 | Svoronos Dawn | Director | Grant | Stock Option (Right to Buy) | 40k | $0.99 | $39.6k | | 06/10/2022 |
| 06/10/2022 | Scopa James Paul | Director | Grant | Stock Option (Right to Buy) | 40k | $0.99 | $39.6k | | 06/10/2022 |
| 06/10/2022 | Lupher, Jr. Mark L. | Director | Grant | Stock Option (Right to Buy) | 40k | $0.99 | $39.6k | | 06/10/2022 |
| 06/10/2022 | Whitcup Scott M | Director | Grant | Stock Option (Right to Buy) | 40k | $0.99 | $39.6k | | 06/10/2022 |
| 06/10/2022 | Machado Patrick | Director | Grant | Stock Option (Right to Buy) | 40k | $0.99 | $39.6k | | 06/10/2022 |
| 06/10/2022 | Machado Patrick | Director | Grant | Stock Option (Right to Buy) | 12.5k | $0.99 | $12.4k | | 06/10/2022 |
| 06/08/2022 | Rakow John | SVP, Genl Counsel, Acting CFO | Grant | Stock Option (Right to Buy) | 250k | $1.09 | $272.5k | | 06/08/2022 |
| 05/23/2022 | Seyedkazemi Setareh | Chief Development Officer | Purchase | Common Stock | 20k | $0.84 | $16.8k | | 05/23/2022 |
| 05/17/2022 | Beckman Richard | Chief Medical Officer | Purchase | Common Stock | 10k | $0.82 | $8.2k | | 05/17/2022 |
| 05/17/2022 | D'Souza Rupert | CFO | Purchase | Common Stock | 10k | $0.83 | $8.3k | | 05/13/2022 |
| 05/16/2022 | Svoronos Dawn | Director | Purchase | Common Stock | 30k | $0.85 | $25.6k | | 05/16/2022 |
| 05/13/2022 | D'Souza Rupert | CFO | Purchase | Common Stock | 10k | $0.86 | $8.6k | | 05/13/2022 |
| 04/20/2022 | Fischer Laurent | CEO, President and Director | Purchase | Common Stock | 25k | $1.11 | $27.8k | | 04/20/2022 |
| 04/19/2022 | Soparkar Peter | COO | Purchase | Common Stock | 21.8k | $1.14 | $24.8k | | 04/19/2022 |
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